Evidence map›Paper›PMID 28731921›Full record

ArticleJournal of pediatric hematology/oncology2017

Loss of CDKN1C in a Recurrent Atypical Teratoid/Rhabdoid Tumor.

Dustin Tran, Sandra Camelo-Piragua, Avneesh Gupta, Kate Gowans, Patricia L Robertson, Rajen Mody, Carl Koschmann

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pediatric hematology/oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Dustin TranDepartments of *Pediatrics, Division of Pediatric Hematology-Oncology †Pathology §Pediatrics, Division of Neurology, University of Michigan, Ann Arbor ‡Division of Pediatric Hematology-Oncology, Beaumont Hospital, Royal Oak, MI.
Sandra Camelo-Piragua
Avneesh Gupta
Kate Gowans
Patricia L Robertson
Rajen Mody
Carl Koschmann
Pediatric Oncology Group · CABeaumont Hospital, Royal Oak · USUniversity of Michigan–Ann Arbor · US

Funding

Sequencing, Analysis, and Interpretation of SequencingUM1HG006508 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PIENTA, KENNETH J., ROBERTS, SCOTT · 2013 to 2016
$7.8M
Targeting ATRX-Deficient Pediatric GBMK08NS099427 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KOSCHMANN, CARL J · 2017 to 2021
$811k
NHGRI NIH HHS UM1 HG006508NINDS NIH HHS K08 NS099427
6 · The paper itself

Abstract

Atypical teratoid/rhabdoid tumor (AT/RT) is a malignant tumor that is commonly associated with biallelic alterations of SMARCB1. Recurrent or refractory AT/RT has not been molecularly characterized as well. We present the case of a child with recurrent AT/RT who underwent clinically integrated molecular profiling (germline DNA and tumor DNA/RNA sequencing). This demonstrated a somatic lesion in CDKN1C alongside hallmark loss of SMARCB1. This data allowed us to explore potential personalized therapies for this patient and expose a molecular driver that may be involved in similar cases.

Indexed as

MutationBiopsyBrainCombined Modality TherapyCyclin-Dependent Kinase Inhibitor p57FemaleHumansImmunohistochemistryInfantMagnetic Resonance ImagingRecurrenceRhabdoid TumorSequence Analysis, DNATeratomaTreatment OutcomeCDKN1C protein, humanCyclin-Dependent Kinase Inhibitor p57

Identifiers

PMID28731921
PMCPMC5656519
OpenAlexW2739282015

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.