Evidence map›Paper›PMID 28731778›Full record

Trial reportJournal of child and adolescent psychopharmacology2017

A Pharmacologic Algorithm for Youth Who Are at High Risk for Bipolar Disorder.

Christopher D Schneck, Kiki D Chang, Manpreet K Singh, Melissa P DelBello, David J Miklowitz

2 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of child and adolescent psychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00943085 nacompletednot on this map

Family-Focused Therapy as Early Treatment for Youth at Risk for Bipolar Disorder

TypeinterventionalSponsorUniversity of California, Los AngelesRan2007 to 2011Enrolled52ConditionsBipolar DisorderArmsFamily-focused therapy, Brief educational treatment
NCT05427123 recruitingnot on this mapstarted 2022, after this paper: background citation

A Collaborative Treatment Network for Youth With or at High Risk for Bipolar Disorder

TypeobservationalSponsorUniversity of California, Los AngelesRan2022 to 2027Enrolled80ConditionsBipolar Disorder, Bipolar I Disorder, Bipolar II Disorder, Other Specified Bipolar and Related DisorderArmsMedication or psychosocial treatment
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 28 citations in OpenAlex.

  1. Trial
  2. Mood Instability in Youth at High Risk for Bipolar Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Christopher D Schneck1 Department of Psychiatry, Helen and Arthur E. Johnson Depression Center, University of Colorado School of Medicine , Aurora, Colorado.
Kiki D Chang2 Department of Psychiatry, Stanford University School of Medicine , Stanford, California.
Manpreet K Singh2 Department of Psychiatry, Stanford University School of Medicine , Stanford, California.
Melissa P DelBello3 Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine , Cincinnati, Ohio.
David J Miklowitz4 Child and Adolescent Mood Disorders Program, UCLA Semel Institute , Los Angeles, California.
Stanford University · USAmerican Academy of Child and Adolescent Psychiatry · USUniversity of Cincinnati Medical Center · USUniversity of Colorado Denver · US

Funding

1/2-Early Intervention for Youth at Risk for Bipolar DisorderR01MH093676 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIKLOWITZ, DAVID JAY · 2012 to 2016
$3.6M
Family-Focused Therapy for Youth with Early-Onset Bipolar or Psychotic Disorders R33MH097007 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIKLOWITZ, DAVID JAY · 2014 to 2016
$853k
Family-Focused Therapy as Early Treatment for Youth at Risk for Bipolar DisorderR34MH077856 · NIMH · UNIVERSITY OF COLORADO · PI MIKLOWITZ, DAVID JAY · 2007 to 2009
$638k
Family-Focused Treatment for Youth with Early-Onset Bipolar or Psychotic DisorderR21MH097007 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIKLOWITZ, DAVID JAY · 2012 to 2013
$439k
NIMH NIH HHS R01 MH093676NIMH NIH HHS R21 MH097007NIMH NIH HHS R33 MH097007NIMH NIH HHS R34 MH077856
6 · The paper itself

Abstract

objectiveDepression and brief periods of manic symptoms are linked to a significant risk of progression to bipolar disorder (BD) in children who have a first-degree relative with BD I or II. However, little evidence exists to guide the pharmacologic management of children with these high-risk phenotypes. We propose a pharmacological treatment algorithm for high-risk youth and present results on its use in a study of children with a first-degree relative with BD.

methodsSubjects were 40 youth (mean 12.7 years, range 9-17 years) who had (1) a first-degree relative with lifetime history of BD I or II, (2) DSM-IV-TR diagnoses of BD not otherwise specified, major depressive disorder or cyclothymic disorder, and (3) active symptoms of depression, mania, or hypomania. Participants and their families were enrolled in a randomized trial examining the effects of two psychosocial interventions on the 1-year course of mood disorder. At study intake, participants received a psychiatric evaluation and were offered medications or had existing medications optimized to decrease symptom severity. During the 1-year study, psychiatrists treated participants using a medication algorithm to treat depressive or manic symptoms as well as comorbid anxiety and/or attention-deficit/hyperactivity disorder.

resultsAt study entry, 25 of 40 (62.5%) of the participants were taking at least one psychiatric medication. At 1 year, nearly an identical proportion were taking medications (22 of 35, 63%). Independent ratings indicated that in 84.7% of the study visits, physicians maintained adherence to the algorithm. No patients experienced antidepressant- or stimulant-induced mania during the study.

conclusionsAn algorithmic approach to pharmacologic interventions may aid in the management of youth (i.e., age <18) at high risk for BD. Future studies should compare outcomes in high-risk patients receiving algorithm-prescribed treatment versus those receiving treatment as usual. CLINICAL TRIAL REGISTRATION INFORMATION: Early Family-Focused Treatment for Youth at Risk for Bipolar Disorder; www.clinicaltrials.gov/ ; NCT00943085.

Indexed as

AlgorithmsBipolar DisorderAdolescentAnxiety DisordersAttention Deficit Disorder with HyperactivityBehavioral SymptomsChildComorbidityEarly Intervention, EducationalFamily TherapyFemaleHumansMajor Depressive DisorderMalePhenotypePsychiatric Status Rating Scalesantidepressantantipsychoticbipolar disorderearly interventionhigh riskmood stabilizerpediatrictreatment

Identifiers

PMID28731778
PMCPMC5689113
OpenAlexW2737848709

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.