ArticleJournal of magnetic resonance imaging : JMRI2018
Susceptibility weighted imaging and quantitative susceptibility mapping of the cerebral vasculature using ferumoxytol.
Article in Journal of magnetic resonance imaging : JMRI, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Fast and robust T1 mapping based on a 3D dual-echo UTE sequence (PETALUTE) for superparamagnetic iron oxide nanoparticle (SPION) biodistribution assessment.Medical physics · 2026Article
- Evaluation of Phantom Doping Materials in Quantitative Susceptibility Mapping.Magnetic resonance in medicine · 2026Article
- Advancements in MRI application in the morphological development of fetal cerebral venous system: a review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Review
- Shedding light on vascular imaging: the revolutionary role of nanotechnology.Journal of nanobiotechnology · 2024Review
- Vascular Aging in the Choroid Plexus: A 7T Ultrasmall Superparamagnetic Iron Oxide (USPIO)-MRI Study.Journal of magnetic resonance imaging : JMRI · 2024Article
- Imaging arterial and venous vessels using Iron Dextran enhanced multi-echo 3D gradient echo MRI at 7T.NMR in biomedicine · 2024Article
- In Vivo Detection of Age-Related Tortuous Cerebral Small Vessels using Ferumoxytol-enhanced 7T MRI.Aging and disease · 2024Article
- On the optimization of 3D inflow-based vascular-space-occupancy (iVASO) MRI for the quantification of arterial cerebral blood volume (CBVa).Magnetic resonance in medicine · 2024Article
- The role of the parenchymal vascular system in cerebrospinal fluid tracer clearance.European radiology · 2023Article
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- Black-Blood Contrast in Cardiovascular MRI.Journal of magnetic resonance imaging : JMRI · 2022Review
- Epiphyseal cartilage canal architecture and extracellular matrix remodeling in mucopolysaccharidosis VII dogs at the onset of postnatal growth.Connective tissue research · 2021Article
- QSM reconstruction challenge 2.0: A realistic in silico head phantom for MRI data simulation and evaluation of susceptibility mapping procedures.Magnetic resonance in medicine · 2021Article
- An Overview of Venous Abnormalities Related to the Development of Lesions in Multiple Sclerosis.Frontiers in neurology · 2021Review
- Revealing vascular abnormalities and measuring small vessel density in multiple sclerosis lesions using USPIO.NeuroImage. Clinical · 2021Article
- Three-Dimensional Iron Oxide Nanoparticle-Based Contrast-Enhanced Magnetic Resonance Imaging for Characterization of Cerebral Arteriogenesis in the Mouse Neocortex.Frontiers in neuroscience · 2021Article
- Heterogeneity of White Matter Hyperintensities in Cognitively Impaired Patients With Cerebral Small Vessel Disease.Frontiers in immunology · 2021Article
- Subvoxel vascular imaging of the midbrain using USPIO-Enhanced MRI.NeuroImage · 2020Article
- Detecting sub-voxel microvasculature with USPIO-enhanced susceptibility-weighted MRI at 7 T.Magnetic resonance imaging · 2020Article
- Sensitivity of quantitative relaxometry and susceptibility mapping to microscopic iron distribution.Magnetic resonance in medicine · 2020Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo demonstrate the potential of imaging cerebral arteries and veins with ferumoxytol using susceptibility weighted imaging (SWI) and quantitative susceptibility mapping (QSM). MATERIALS AND
methodsThe relationships between ferumoxytol concentration and the apparent susceptibility at 1.5T, 3T, and 7T were determined using phantom data; the ability of visualizing subvoxel vessels was evaluated using simulations; and the feasibility of using ferumoxytol to enhance the visibility of small vessels was confirmed in three healthy volunteers at 7T(with doses 1 mg/kg to 4 mg/kg). The visualization of the lenticulostriate arteries and the medullary veins was assessed by two raters and the contrast-to-noise ratios (CNRs) of these vessels were measured.
resultsThe relationship between ferumoxytol concentration and susceptibility was linear with a slope 13.3 ± 0.2 ppm·mg
conclusionThe CNR for cerebral vessels with ferumoxytol can be enhanced using SWI, and the apparent susceptibilities of the arteries can be reliably quantified using QSM. This approach improves the imaging of the entire vascular system outside the capillaries and may be valuable for a variety of neurodegenerative diseases which involve the microvasculature. LEVEL OF EVIDENCE: 1 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2018;47:621-633.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.