ArticleHuman brain mapping2017
Integration of white matter network is associated with interindividual differences in psychologically mediated placebo response in migraine patients.
Article in Human brain mapping, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Brain network properties in chronic pain-a systematic review and meta-analysis of graph-based connectivity metrics.Frontiers in neuroscience · 2025Pooled it
- Revealing the Neural Mechanism Underlying the Effects of Acupuncture on Migraine: A Systematic Review.Frontiers in neuroscience · 2021Pooled it
- White matter tract microstructure of the mPFC-amygdala predicts interindividual differences in placebo response related to treatment in migraine patients.Human brain mapping · 2019Trial
- Alterations of White Matter Structural Brain Network in Children With Sensorineural Hearing Loss: A Graph Theory Analysis for Auditory Sensitivity Period.Neural plasticity · 2026Article
- Long-term risk of late-life depression in widowed elderly: a five-year follow-up study.BMC geriatrics · 2025Article
- Involvement of the cerebellum in structural connectivity enhancement in episodic migraine.The journal of headache and pain · 2024Article
- Evaluation of a Clustering Approach to Define Distinct Subgroups of Patients With Migraine to Select Electroacupuncture Treatments.Neurology · 2023Article
- Bibliometric Analysis of 100 Most Highly Cited Publications on Acupuncture for Migraine.Journal of pain research · 2023Article
- Cortical morphology predicts placebo response in multiple sclerosis.Scientific reports · 2022Article
- Circulating exosomal microRNA profiles in migraine patients receiving acupuncture treatment: A placebo-controlled clinical trial.Frontiers in molecular neuroscience · 2022Article
- Altered brain structural topological properties and its correlations with clinical characteristics in episodic migraine without aura.Neuroradiology · 2021Article
- Disconnectome of the migraine brain: a "connectopathy" model.The journal of headache and pain · 2021Article
- Article
- Dapagliflozin reverses the imbalance of T helper 17 and T regulatory cells by inhibiting SGK1 in a mouse model of diabetic kidney disease.FEBS open bio · 2021Article
- Altered local and distant functional connectivity density in chronic migraine: a resting-state functional MRI study.Neuroradiology · 2021Article
- Disrupted Topological Organization in White Matter Networks in Unilateral Sudden Sensorineural Hearing Loss.Frontiers in neuroscience · 2021Article
- Scientific Knowledge Graph of Acupuncture for Migraine: A Bibliometric Analysis from 2000 to 2019.Journal of pain research · 2021Article
- Neuroimaging features of whole-brain functional connectivity predict attack frequency of migraine.Human brain mapping · 2020Article
- White matter changes in chronic and episodic migraine: a diffusion tensor imaging study.The journal of headache and pain · 2020Observational
- Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Individual differences of brain changes of neural communication and integration in the modular architecture of the human brain network exist for the repeated migraine attack and physical or psychological stressors. However, whether the interindividual variability in the migraine brain connectome predicts placebo response to placebo treatment is still unclear. Using DTI and graph theory approaches, we systematically investigated the topological organization of white matter networks in 71 patients with migraine without aura (MO) and 50 matched healthy controls at three levels: global network measure, nodal efficiency, and nodal intramodule/intermodule efficiency. All patients participated in an 8-week sham acupuncture treatment to induce analgesia. In our results, 30% (n = 21) of patients had 50% change in migraine days from baseline after placebo treatment. At baseline, abnormal increased network integration was found in MO patients as compared with the HC group, and the increased global efficiency before starting clinical treatment was associated with their following placebo response. For nodal efficiency, significantly increased within-subnetwork nodal efficiency and intersubnetwork connectivity of the hippocampus and middle frontal gyrus in patients' white matter network were correlated with the responses of follow-up placebo treatment. Our findings suggested that the trait-like individual differences in pain-related maladaptive stress interfered with and diminished the capacity of chronic pain modulation differently, and the placebo response for treatment could be predicted from a prior white matter network modular structure in migraineurs. Hum Brain Mapp 38:5250-5259, 2017. © 2017 Wiley Periodicals, Inc.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.