ArticleNMR in biomedicine2017
Localized MRS reliability of in vivo glutamate at 3 T in shortened scan times: a feasibility study.
Article in NMR in biomedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Role of magnetic resonance spectroscopy in cerebral glutathione quantification for youth mental health: A systematic review.Early intervention in psychiatry · 2020Pooled it
- Acute change in anterior cingulate cortex GABA, but not glutamine/glutamate, mediates antidepressant response to citalopram.Psychiatry research. Neuroimaging · 2017Trial
- Aspartate in the Brain: A Review.Neurochemical research · 2025Review
- A pilot spectroscopy study of adversity in adolescents.Biomarkers in neuropsychiatry · 2021Article
- In Vivo Brain GSH: MRS Methods and Clinical Applications.Antioxidants (Basel, Switzerland) · 2021Review
- Mapping Disease Course Across the Mood Disorder Spectrum Through a Research Domain Criteria Framework.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Article
- Reduced adaptation of glutamatergic stress response is associated with pessimistic expectations in depression.Nature communications · 2021Observational
- Localized MRS reliability of in vivo glutamate at 3 T in shortened scan times: A feasibility study - Efforts to improve rigor and reproducibility.NMR in biomedicine · 2019Article
- Short-acquisition-time JPRESS and its application to paediatric brain tumours.Magma (New York, N.Y.) · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Glutamate is the prime excitatory neurotransmitter in the mammalian brain and has been implicated in a wide range of psychiatric conditions. To improve the applicability and clinical reach of magnetic resonance spectroscopy (MRS), research is needed to develop shortened, yet reliable, MRS scanning procedures for standard 1.5-3-T clinical magnetic resonance imaging (MRI) systems, particularly with young or vulnerable populations unable to tolerate longer protocols. To this end, we evaluated the test-retest reliability of a shortened J-resolved MRS sequence in healthy adolescents (n = 22) aged 12-14 years. Participants underwent a series of sequential 6-min MRS scans, with the participants remaining in situ between successive scans. Glutamate and other metabolites were acquired from the rostral anterior cingulate cortex, as glutamatergic function in this region has been implicated in a number of psychiatric illnesses. Thirteen neurochemicals were quantified as ratios to total creatine, and reliability scores were expressed as the percentage difference between the two scans for each metabolite. Test-retest assessment of glutamate was reliable, as scores were less than 10% different (7.1 ± 4.2%), and glutamate values across scans were significantly correlated (Pearson r = 0.680, p < 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.