ArticleThe ISME journal2017
Novel chaperonins are prevalent in the virioplankton and demonstrate links to viral biology and ecology.
Article in The ISME journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Community ecology and functional potential of bacteria, archaea, eukarya and viruses in Guerrero Negro microbial mat.Scientific reports · 2024Article
- The Viral Fraction Metatranscriptomes of Lake Baikal.Microorganisms · 2022Article
- Towards an integrative view of virus phenotypes.Nature reviews. Microbiology · 2022Review
- Novel Viral DNA Polymerases From Metagenomes Suggest Genomic Sources of Strand-Displacing Biochemical Phenotypes.Frontiers in microbiology · 2022Article
- Moisture modulates soil reservoirs of active DNA and RNA viruses.Communications biology · 2021Article
- RaFAH: Host prediction for viruses of Bacteria and Archaea based on protein content.Patterns (New York, N.Y.) · 2021Article
- Viral elements and their potential influence on microbial processes along the permanently stratified Cariaco Basin redoxcline.The ISME journal · 2020Article
- Article
- Minimum Information about an Uncultivated Virus Genome (MIUViG).Nature biotechnology · 2019Article
- Phage puppet masters of the marine microbial realm.Nature microbiology · 2018Review
- Xanthomonas citri jumbo phage XacN1 exhibits a wide host range and high complement of tRNA genes.Scientific reports · 2018Article
- Viruses of archaea: Structural, functional, environmental and evolutionary genomics.Virus research · 2018Review
- Family A DNA Polymerase Phylogeny Uncovers Diversity and Replication Gene Organization in the Virioplankton.Frontiers in microbiology · 2018Article
- Single-Ring Intermediates Are Essential for Some Chaperonins.Frontiers in molecular biosciences · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Chaperonins are protein-folding machinery found in all cellular life. Chaperonin genes have been documented within a few viruses, yet, surprisingly, analysis of metagenome sequence data indicated that chaperonin-carrying viruses are common and geographically widespread in marine ecosystems. Also unexpected was the discovery of viral chaperonin sequences related to thermosome proteins of archaea, indicating the presence of virioplankton populations infecting marine archaeal hosts. Virioplankton large subunit chaperonin sequences (GroELs) were divergent from bacterial sequences, indicating that viruses have carried this gene over long evolutionary time. Analysis of viral metagenome contigs indicated that: the order of large and small subunit genes was linked to the phylogeny of GroEL; both lytic and temperate phages may carry group I chaperonin genes; and viruses carrying a GroEL gene likely have large double-stranded DNA (dsDNA) genomes (>70 kb). Given these connections, it is likely that chaperonins are critical to the biology and ecology of virioplankton populations that carry these genes. Moreover, these discoveries raise the intriguing possibility that viral chaperonins may more broadly alter the structure and function of viral and cellular proteins in infected host cells.
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