Evidence map›Paper›PMID 28731372›Full record

Trial reportMultiple sclerosis (Houndmills, Basingstoke, England)2018

Exploring the effect of vitamin D

Linda Rolf, Anne-Hilde Muris, Amandine Mathias, Renaud Du Pasquier, Inga Koneczny, Giulio Disanto, Jens Kuhle, Sreeram Ramagopalan, Jan Damoiseaux, Joost Smolders and 1 more

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Multiple sclerosis (Houndmills, Basingstoke, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Review
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  5. Article
  6. Review
  7. Immune Modulatory Effects of Vitamin D on Herpesvirus Infections.International journal of molecular sciences · 2025
    Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Identifying the culprits in neurological autoimmune diseases.Journal of translational autoimmunity · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Linda RolfSchool for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands/Academic MS Center Limburg, Zuyderland Medical Center, Sittard, The Netherlands/Central Diagnostic Laboratory, Maastricht University Medical Centre, Maastricht, The Netherlands.
Anne-Hilde MurisSchool for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands/Academic MS Center Limburg, Zuyderland Medical Center, Sittard, The Netherlands.
Amandine MathiasLaboratory of Neuroimmunology, Center of Research in Neurosciences, Department of Clinical Neurosciences, Lausanne University Hospital, Lausanne, Switzerland.
Renaud Du PasquierLaboratory of Neuroimmunology, Center of Research in Neurosciences, Department of Clinical Neurosciences, Lausanne University Hospital, Lausanne, Switzerland.
Inga KonecznySchool for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands.
Giulio DisantoNeurocenter of Southern Switzerland (NSI), Ospedale Civico, Lugano, Switzerland.
Jens KuhleNeurologic Clinic and Policlinic, Departments of Medicine, Biomedicine, and Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
Sreeram RamagopalanEvidera, London, UK.
Jan DamoiseauxCentral Diagnostic Laboratory, Maastricht University Medical Center, Maastricht, The Netherlands.
Joost SmoldersAcademic MS Center Limburg, Zuyderland Medical Center, Sittard, The Netherlands/Department of Neurology, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands.
Raymond HuppertsSchool for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands/Academic MS Center Limburg, Zuyderland Medical Center, Sittard, The Netherlands.
Maastricht University Medical Centre · NLMaastricht University · NLUniversity of Lausanne · CHEVRAZ (United Kingdom) · GBOspedale regionale di Lugano · CHUniversity Hospital of Basel · CH

Funding

Austrian Science Fund FWF J 3545
6 · The paper itself

Abstract

backgroundEpstein-Barr virus (EBV) infection and vitamin D insufficiency are potentially interacting risk factors for multiple sclerosis (MS).

objectivesTo investigate the effect of high-dose vitamin D

methodsThis study utilized blood samples from a randomized controlled trial in RRMS patients receiving either vitamin D

resultsThe median antibody levels against EBNA-1, but not VCA and CMV, significantly reduced in the vitamin D

conclusionHigh-dose vitamin D

Indexed as

Dietary SupplementsAdultAntibodies, ViralCholecalciferolEpstein-Barr Virus InfectionsEpstein-Barr Virus Nuclear AntigensFemaleHumansMaleMiddle AgedMultiple Sclerosis, Relapsing-RemittingAntibodies, ViralCholecalciferolEBV-encoded nuclear antigen 1Epstein-Barr Virus Nuclear AntigensAntibodiesEBNA-1Epstein–Barr virusmultiple sclerosissupplementationvitamin D

Identifiers

PMID28731372
PMCPMC6108041
OpenAlexW2738599261

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.