Evidence map›Paper›PMID 28731260›Full record

ReviewBioEssays : news and reviews in molecular, cellular and developmental biology2017

Transcriptional regulation of APP by apoE: To boldly go where no isoform has gone before: ApoE, APP transcription and AD: Hypothesised mechanisms and existing knowledge gaps.

Liying Corinne Lee, Michele Q L Goh, Edward H Koo

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in BioEssays : news and reviews in molecular, cellular and developmental biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Liying Corinne LeeDepartment of Physiology, Yong Loo Lin School of Medicine, National University Health System, Singapore, Singapore.
Michele Q L GohDepartment of Medicine, Yong Loo Lin School of Medicine, National University Health System, Singapore, Singapore.
Edward H KooDepartment of Medicine, Yong Loo Lin School of Medicine, National University Health System, Singapore, Singapore.
National University Health System · SGUniversity of California, San Diego · US

Funding

Mechanisms of abeta induced dysfunction in hippocampal neuronal circuitryR01NS084324 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KOO, EDWARD H., LEUTGEB, STEFAN · 2014 to 2018
$2.7M
Synaptic damage in models of beta-amyloid associated pathologyR01AG032179 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KOO, EDWARD H. · 2007 to 2011
$1.6M
NIA NIH HHS R01 AG032179NINDS NIH HHS R01 NS084324
6 · The paper itself

Abstract

Alzheimer's disease (AD) is the most common form of dementia that gradually disrupts the brain network to impair memory, language and cognition. While the amyloid hypothesis remains the leading proposed mechanism to explain AD pathophysiology, anti-amyloid therapeutic strategies have yet to translate into useful therapies, suggesting that amyloid β-protein and its precursor, the amyloid precursor protein (APP) are but a part of the disease cascade. Further, risk of AD can be modulated by a number of factors, the most impactful being the ɛ4 isoform of apolipoprotein E (apoE). A recent study reported a novel isoform-dependent transcriptional regulation of APP by apoE. These interesting new results add to the myriad of mechanisms that have been proposed to explain how apoE4 enhances AD risk, highlighting the complexities of not only apoE and AD pathophysiology, but also of disease itself. Also see the video abstract here: https://youtu.be/yd14MBdPkCY.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnimalsApolipoproteins EGene Expression RegulationHumansProtein IsoformsTranscription, GeneticAmyloid beta-PeptidesAmyloid beta-Protein PrecursorApolipoproteins EProtein IsoformsAlzheimer's diseaseApoEAPPAβtranscription

Identifiers

PMID28731260
PMCPMC5647194
OpenAlexW2737442224

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.