ArticleModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc2017
Targeted next-generation sequencing supports epidermoid metaplasia of the esophagus as a precursor to esophageal squamous neoplasia.
Article in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 63 citations in OpenAlex.
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- Esophageal Epidermoid Metaplasia With Histologic Clearance: Proposed Strategy for Ongoing Surveillance.ACG case reports journal · 2026Article
- Esophageal epidermoid metaplasia: diagnostic challenges and therapeutic strategies.Journal of the Canadian Association of Gastroenterology · 2025Article
- Diagnosis and management of a rare case of esophageal epidermoid metaplasia: A case report.World journal of gastrointestinal endoscopy · 2025Article
- Esophageal Lichen Planus-Contemporary Insights and Emerging Trends.Biomedicines · 2025Review
- Superficial esophageal squamous cell carcinoma with esophageal lichen planus and esophageal epidermoid metaplasia treated with endoscopic submucosal dissection.Clinical journal of gastroenterology · 2025Article
- Emergence of esophageal epidermoid metaplasia following eradication of squamous cell carcinoma.iGIE : innovation, investigation and insights · 2025Article
- Esophageal Epidermoid Metaplasia Treated With Endoscopic Submucosal Dissection.ACG case reports journal · 2025Article
- Development of Esophageal Epidermoid Metaplasia in a Pediatric Patient After Stevens-Johnson Syndrome.ACG case reports journal · 2024Article
- Role of Endoscopy in Management of Upper Gastrointestinal Cancers.Diseases (Basel, Switzerland) · 2022Review
- Esophageal lichen planus: Current knowledge, challenges and future perspectives.World journal of gastroenterology · 2022Review
- Endoscopic features of esophageal high-grade intraepithelial neoplasia dominated by cytological atypia.American journal of cancer research · 2022Article
- Article
- White esophageal lesions in a patient with scleroderma: epidermoid metaplasia.Gastroenterology report · 2020Article
- Nipple-Like Focal Distal Esophageal Epidermoid Metaplasia.GE Portuguese journal of gastroenterologyArticle
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Esophageal epidermoid metaplasia is a rare condition that involves the proximal-to-middle third of the esophagus. It is sharply demarcated and defined histologically by epithelial hyperplasia, a prominent granular cell layer, and superficial hyperorthokeratosis. In addition, preliminary studies have suggested an association between esophageal epidermoid metaplasia and esophageal squamous neoplasia (squamous dysplasia and esophageal squamous cell carcinoma). To further characterize esophageal epidermoid metaplasia and better define its relationship to squamous neoplasia of the esophagus, we performed targeted next-generation sequencing on uninvolved esophageal squamous mucosa and matching esophageal epidermoid metaplasia specimens from 18 patients. Further, we evaluated both synchronous and metachronous high-grade squamous dysplasia/esophageal squamous cell carcinoma by next-generation sequencing from 5 of the 18 (28%) patients, and compared these findings to corresponding esophageal epidermoid metaplasia specimens. Targeted next-generation sequencing revealed 12 of 18 (67%) esophageal epidermoid metaplasia specimens' harbored alterations in genes often associated with esophageal squamous cell carcinoma. The most frequently mutated genes consisted of TP53 (n=10), PIK3CA (n=2), EGFR (n=2), MYCN (n=1), HRAS (n=1), and the TERT promoter (n=1). Sequencing of synchronous and metachronous high-grade squamous dysplasia/esophageal squamous cell carcinoma identified shared genetic alterations with corresponding esophageal epidermoid metaplasia specimens that suggests a clonal relationship between these entities. In addition, the presence of a TP53 mutation in esophageal epidermoid metaplasia specimens correlated with concurrent or progression to high-grade squamous dysplasia/esophageal squamous cell carcinoma. No genetic alterations were detected in uninvolved esophageal squamous mucosa. On the basis of these findings, we conclude esophageal epidermoid metaplasia is a precursor to in situ and invasive esophageal squamous neoplasia. Further, the detection of TP53 mutations in esophageal epidermoid metaplasia specimens may serve as an early detection biomarker for high-grade squamous dysplasia/esophageal squamous cell carcinoma.
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