ArticleModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc2017
Risk assessment in solitary fibrous tumors: validation and refinement of a risk stratification model.
Article in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 214 papers, 3 of them syntheses that pooled it.
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Who cites it
214 citing papers in PubMed, 3 syntheses or guidelines pooled it, 421 citations in OpenAlex.
- Retroperitoneal Sarcoma (RPS): A Systematic Review.Current oncology reports · 2025Pooled it
- Solitary fibrous tumor of the prostate: a case report and the systematic review of 74 published cases.Frontiers in oncology · 2025Pooled it
- A review of solitary fibrous tumor/hemangiopericytoma tumor and a comparison of risk factors for recurrence, metastases, and death among patients with spinal and intracranial tumors.Neurosurgical review · 2021Pooled it
- Doege-Potter syndrome caused by a solitary fibrous tumor arising from the greater omentum: a case report.Clinical journal of gastroenterology · 2026Article
- Carbon-Ion Radiation Therapy for Unresectable Solitary Fibrous Tumor of the Intermediate Category: A Nationwide Multi-institutional Observational Study by the Japan Carbon-Ion Radiation Oncology Study Group.Advances in radiation oncology · 2026Article
- Article
- Solitary fibrous tumour of the pleura: evolution in surgical management and challenges in prognostic evaluation.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Recurrent Pleural Solitary Fibrous Tumor: A Case Report and Brief Literature Review.Reports (MDPI) · 2026Article
- Hypoglycemia unmasking a giant pulmonary solitary fibrous tumor: a case report.Journal of medical case reports · 2026Article
- Sellar Solitary Fibrous Tumor Mimicking Pituitary Adenoma: Diagnostic Pitfalls, Contemporary Pathological Classification, and Management Considerations.Diagnostics (Basel, Switzerland) · 2026Article
- Laparoscopic Resection of a Mesorectal Solitary Fibrous Tumor: A Case Report and Review of the Literature.Cureus · 2026Article
- Intracardiac Neoplastic Extension of a Malignant Solitary Fibrous Tumor Mimicking a Giant Left Atrial Thrombus.Cureus · 2026Article
- Intrapulmonary solitary fibrous tumor: clinicopathological analysis of 29 cases with emphasis on morphological spectrum and immunohistochemical profile.Diagnostic pathology · 2026Article
- Solitary Fibrous Tumor of the Abdominal Wall With Long-Term Progressive Enlargement and Malignant Features.Cureus · 2026Article
- Platelet-to-lymphocyte ratio and systemic inflammation response index are the optimal combination for risk stratification in patients with nasopharyngeal carcinoma.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Systemic Therapy for Solitary Fibrous Tumor.Current treatment options in oncology · 2026Review
- Perioperative Continuous Glucose Monitoring During Resection of a Giant Intrathoracic Solitary Fibrous Tumour Associated With Doege-Potter Syndrome.Interdisciplinary cardiovascular and thoracic surgery · 2026Article
- Outcomes of radiologically diagnosed solitary fibrous tumours of the pleura.ERJ open research · 2026Article
- Review
- Perioperative Decision-Making for a Solitary Fibrous Tumor of the Pleura: Lessons from Two Cases and Current Evidence.Diagnostics (Basel, Switzerland) · 2026Article
154 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Solitary fibrous tumors are an uncommon sarcoma type characterized by NAB2-STAT6 gene fusion. While solitary fibrous tumors metastasize in 5-25% of cases, it has historically been challenging to determine which specific tumor and patient characteristics predict aggressive behavior. We previously reported on a novel risk stratification scheme for solitary fibrous tumors incorporating patient age, tumor size, and mitotic activity to predict risk of metastasis. Herein we validate this risk stratification scheme in an independent, lower-risk population of 79 patients with primary non-meningeal solitary fibrous tumors, and propose incorporating tumor necrosis as a fourth variable to further improve the risk score. Fifty-seven percent of cases were considered low risk, 29% intermediate risk, and 14% high risk for metastasis. Of 50 patients with sufficient clinical follow-up data, no metastases developed in the low-risk patients (n=23), while there was a 7% 10-year metastatic risk in the intermediate risk group (n=17), and a 49% 5-year metastatic risk for the high-risk patients (n=10). When tumor necrosis was added as a fourth variable to the model, predictive power was enhanced. Under the revised stratification, the proportion of tumors identified as low risk increased to 66%, with no metastasis at 10 years, intermediate risk cases comprised 24% with 10% risk of metastasis at 10 years, and high risk comprised 10% of cases with 73% risk of metastasis at 5 years. In Kaplan-Meier analysis, this fourth-variable stratification provided significant discrimination between the risk groups (P=0.0005). These findings confirmed the clinical utility of our previously published risk stratification model and support the inclusion of necrosis as a fourth variable in the model.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.