Evidence map›Paper›PMID 28730928›Full record

ArticleMolecular imaging

Feasibility of Na

Maria I Menendez, Bianca Hettlich, Lai Wei, Michael V Knopp

Open access · goldAbstract read
In one paragraph

Article in Molecular imaging. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Advances in molecular imaging for osteoarthritis.Connective tissue research · 2025
    Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. [Frontiers in medicine · 2021
    Article
  7. Post-traumatic osteoarthritis following ACL injury.Arthritis research & therapy · 2020
    Review
  8. Review
  9. PET-MRI for the Study of Metabolic Bone Disease.Current osteoporosis reports · 2018
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Maria I Menendez1 Department of Radiology, Wright Center of Innovation in Biomedical Imaging, The Ohio State University, Columbus, OH, USA.
Bianca Hettlich1 Department of Radiology, Wright Center of Innovation in Biomedical Imaging, The Ohio State University, Columbus, OH, USA.
Lai Wei3 Center for Biostatistics, The Ohio State University, Columbus, OH, USA.
Michael V Knopp1 Department of Radiology, Wright Center of Innovation in Biomedical Imaging, The Ohio State University, Columbus, OH, USA.
The Ohio State University · US

Funding

IROC: Enhancing local enrolling site radiological data capture capabilities for NCTN trialsU24CA180803 · NCI · AMERICAN COLLEGE OF RADIOLOGY · PI Thomas J. FitzGerald, MICHAEL V KNOPP · 2014 to 2026
$116.2M
Image-guided, Transcatheter Peptide Receptor Radio Therapy for Prostate CancerR01EB022134 · NIBIB · OHIO STATE UNIVERSITY · PI KNOPP, MICHAEL V, TWEEDLE, MICHAEL F · 2016 to 2019
$2.3M
HSRD VA SDR 10-012NCI NIH HHS U24 CA180803NIBIB NIH HHS R01 EB022134
6 · The paper itself

Abstract

purposeTo assess and quantify by molecular imaging knee osseous metabolic changes serially in an in vivo canine model of posttraumatic osteoarthritis (PTOA) of the knee utilizing sodium fluoride (Na MATERIALS AND

methodsSodium fluoride PET imaging of 5 canines was performed prior to anterior cruciate ligament transection (ACLT) and 2 times post-ACLT (3 and 12 weeks). The PET/CT was coregistered with MRI, enabling serial anatomically guided visual and quantitative three-dimensional (3D) region of interest (ROI) assessment by maximum standardized uptake value.

resultsPrior to ACLT, every 3D ROI assessed in both knees showed no Na

conclusionThis study demonstrated that Na

Indexed as

AnimalsArthritis, ExperimentalBone and BonesDogsJointsMagnetic Resonance ImagingMaleOsteoarthritisPositron Emission Tomography Computed Tomographyanimal modelbone remodelingknee osteoarthritisMRImultimodality imagingNa-18fluoridePET/CTpost-traumatic osteoarthritis

Identifiers

PMID28730928
PMCPMC5524230
OpenAlexW2737862407

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.