ArticleInternational wound journal2017
Changes in the extracellular matrix surrounding human chronic wounds revealed by 2-photon imaging.
Article in International wound journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Regenerative Performance and Structural Persistence of Silk Fibroin Matrices in Human Infected and Non-Infected Ex Vivo Wounds.Biomimetics (Basel, Switzerland) · 2026Article
- Mechanical Stretch-Induced Interlayer Coordination between MMP2 and COL17A1 Exacerbates Regenerative Exhaustion in Skin.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Optimizing wound healing: insights from phytochemicals and advanced therapies.Inflammopharmacology · 2025Review
- Microenvironment of diabetic foot ulcers: Implications for healing and therapeutic strategies.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2025Review
- Liver Fluke-Derived Molecules Accelerate Skin Repair Processes in a Mouse Model of Type 2 Diabetes Mellitus.International journal of molecular sciences · 2024Article
- Dysregulated S100A9 Expression Impairs Matrix Deposition in Chronic Wounds.International journal of molecular sciences · 2024Article
- Label-free quantification of imaging features in the extracellular matrix of left and right-sided colon cancer tissues.Scientific reports · 2024Article
- Article
- Mechanism and application of fibrous proteins in diabetic wound healing: a literature review.Frontiers in endocrinology · 2024Review
- Innovative Treatment Strategies to Accelerate Wound Healing: Trajectory and Recent Advancements.Cells · 2022Review
- The Impact of Prolonged Inflammation on Wound Healing.Biomedicines · 2022Article
- Membrane curvature and connective fiber alignment in guinea pig round window membrane.Acta biomaterialia · 2021Article
- Hybrid fusion protein as a dual protease inhibitor for the healing of chronic wounds.Biotechnology progress · 2021Article
- Extracellular matrix and cellular senescence in venous leg ulcers.Scientific reports · 2021Article
- Adipose-derived stromal cells for nonhealing wounds: Emerging opportunities and challenges.Medicinal research reviews · 2021Review
- An observational pilot study using a purified reconstituted bilayer matrix to treat non-healing diabetic foot ulcers.International wound journal · 2020Observational
- The role of extracellular matrix in the pathophysiology of diabetic wounds.Matrix biology plus · 2020Article
- Targeting mechanotransduction mechanisms and tissue weakening signals in the human amniotic membrane.Scientific reports · 2019Article
- Mechanoreciprocity in cell migration.Nature cell biology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic wounds are a growing problem worldwide with no effective therapeutic treatments available. Our objective was to understand the composition of the dermal tissue surrounding venous leg ulcers and diabetic foot ulcers (DFU). We used novel 2-photon imaging techniques alongside classical histology to examine biopsies from the edges of two common types of chronic wound, venous leg ulcers and DFU. Compared to normal intact skin, we found that collagen levels are significantly reduced throughout the dermis of venous leg ulcer biopsies and DFU, with a reduction in both fibril thickness and abundance. Both wound types showed a significant reduction in elastin in the upper dermis, but in DFU, the loss was throughout the dermis. Loss of extracellular matrix correlated with high levels of CD68- and CD18-positive leukocytes. 2-photon imaging of the extracellular matrix in the intact tissue surrounding a chronic wound with a hand-held device may provide a useful clinical indicator on the healing progression or deterioration of these wounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.