ReviewJournal of clinical immunology2017
Selective IgM Deficiency: Clinical and Laboratory Features of 17 Patients and a Review of the Literature.
Review in Journal of clinical immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Low IgM Levels in Adult IEI: Classification Challenges and Clinical Implications.Journal of clinical immunology · 2026Article
- Selective IgM deficiency: evaluation of 75 patients according to different diagnostic criteria.Immunologic research · 2024Observational
- Refractory and Recurrent Skin Manifestations in an Adult With Selective Immunoglobulin M Deficiency.Cureus · 2024Article
- Selective IgM Deficiency: Evidence, Controversies, and Gaps.Diagnostics (Basel, Switzerland) · 2023Review
- Treatment with IgM-enriched intravenous immunoglobulins enhances clearance of stroke-associated bacterial lung infection.Immunology · 2022Article
- Skin Manifestations in Patients with Selective Immunoglobulin E Deficiency.Journal of clinical medicine · 2022Article
- Evaluation of the health status outcome among inpatients treated for Amphetamine Addiction.Saudi journal of biological sciences · 2022Article
- Spectrum of Disease Manifestations in Patients with Selective Immunoglobulin E Deficiency.Journal of clinical medicine · 2021Article
- Past, Present, and Future of The Journal of Clinical Immunology, the International Journal of Inborn Errors of Immunity.Journal of clinical immunology · 2020Article
- Neurolisteriosis in a previously asymptomatic patient with serum IgM deficiency: a case report.BMC neurology · 2020Article
- The epidemiology and clinical features of selective immunoglobulin M deficiency: A single-center study in China.Journal of clinical laboratory analysis · 2020Article
- The antibody/microbiota interface in health and disease.Mucosal immunology · 2020Review
- Post-Craniopharyngioma and Cranial Nerve-VI Palsy Update on a MS Patient with Major Depression and Concurrent Neuroimmune Conditions.Brain sciences · 2019Article
- Acute-onset Autoimmune Hepatitis in a Patient with Selective Immunoglobulin M Deficiency.Internal medicine (Tokyo, Japan) · 2019Article
- Challenges in investigating patients with isolated decreased serum IgM: The SIMcal study.Scandinavian journal of immunology · 2019Article
- Plasma therapy leads to an increase in functional IgA and IgM concentration in the blood and saliva of a patient with X-linked agammaglobulinemia.Journal of translational medicine · 2019Article
- Defining Primary Selective IgM Deficiency.Journal of clinical immunology · 2019Article
- Autoimmunity and immunodeficiency at the crossroad: autoimmune disorders as the presenting feature of selective IgM deficiency.BMJ case reports · 2019Article
- Comprehensive clinical and immunological features of 62 adult patients with selective primary IgM deficiency.American journal of clinical and experimental immunology · 2019Article
- IgM Augments Complement Bactericidal Activity with Serum from a Patient with a Novel CD79a Mutation.Journal of clinical immunology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
purposePrimary selective IgM deficiency (sIgMD) is a primary immunodeficiency with unclear pathogenesis and a low number of published cases.
methodsWe reviewed clinical and laboratory manifestations of 17 sIgMD patients. Serum IgM, IgG, and its subclasses, IgA, IgE, antibodies against tetanus toxoid, pneumococcal polysaccharides and Haemophilus influenzae type b, isohemagglutinins, and T and B lymphocyte subsets, expressions of IgM on B cells and B lymphocyte production of IgM were compared with previously reported case reports and a small series of patients, which included 81 subjects in total.
resultsWe found that some patients in our cohort (OC) and published cases (PC) had increased IgE levels (OC 7/15; PC 21/37), decreased IgG4 levels (OC 5/14), very low titers of isohemagglutinins (OC 8/8; PC 18/21), increased transitional B cell counts (OC 8/9), decreased marginal zone B cell counts (OC 8/9), and increased 21
conclusionsLow IgM levels are associated with various immunopathological disorders; however, pathogenic mechanisms leading to decreased IgM serum level in selective IgM deficiency remain unclear. Moreover, it is difficult to elucidate how strong these associations are and if these immunopathological conditions are primary or secondary.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.