ReviewClinical & experimental metastasis2017
The pathogenesis, diagnosis, and management of metastatic tumors to the ovary: a comprehensive review.
Review in Clinical & experimental metastasis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
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Who cites it
80 citing papers in PubMed.
- Two case reports of gastric signet ring cell carcinoma with pulmonary metastasis manifesting as diffuse ground-glass opacities and pleural involvement: an atypical imaging pattern mimicking lung infection.Translational cancer research · 2026Article
- Diagnostic significance of cancer antigen 125/carcinoembryonic antigen ratio combined with IOTA-ADNEX model in discriminating between primary ovarian cancer and ovarian metastases.Quantitative imaging in medicine and surgery · 2026Article
- DNA methylation profiling enables subclassification of mucinous ovarian carcinoma and distinguishes it from extraovarian mucinous metastases.Cell reports. Medicine · 2026Article
- MRI features of ovarian metastases from appendiceal tumors and primary ovarian mucinous carcinoma: a comparative study.Japanese journal of radiology · 2026Article
- Article
- Primary Small Intestinal Adenocarcinoma Presenting as Ovarian Metastasis With Obstructive Symptoms: A Case Report.Cureus · 2026Article
- Occult metastasis of hormone receptor-positive breast cancer to the ovary: A case report and literature review.Medicine · 2026Review
- Proteomic profiling identifies prognostic signature for Krukenberg tumor of gastrointestinal origin.iScience · 2026Article
- Isolated Unilateral Ovarian Metastasis from Breast Cancer Demonstrated byMolecular imaging and radionuclide therapy · 2026Article
- Signet-ring cell carcinoma of the appendix presenting as diffuse uterine involvement: a case report and literature review.Frontiers in oncology · 2026Article
- Laparoscopic Ovarian Metastasectomy During Intraperitoneal Administration of Paclitaxel Chemotherapy for Gastric Cancer: A Report of Six Cases.Case reports in surgery · 2026Article
- Characterizing patients who underwent ovarian tissue cryopreservation at a large academic center in the United States.F&S reports · 2025Article
- Contribution of laparoscopic surgery to the diagnosis of ovarian metastasis from thymoma: A rare case and review of the literature.Gynecologic oncology reports · 2025Article
- Occult lobular breast carcinoma presenting as bilateral ovarian masses: A case report.International journal of surgery case reports · 2025Article
- Pictorial review of bilateral adnexal lesions.Abdominal radiology (New York) · 2025Review
- Invasive Lobular Carcinoma Metastasis to the Female Genital Tract: A Systematic Search and Review of Case Reports and Case Series.Diagnostics (Basel, Switzerland) · 2025Review
- Asian consensus on normothermic intraperitoneal and systemic treatment for gastric cancer with peritoneal metastasis.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2025Article
- Ovarian metastasis from lobular breast carcinoma: A case report with review of literature.Radiology case reports · 2025Article
- Postoperative metastatic Krukenberg tumors withOncology letters · 2025Article
- MRI characteristics of ovarian metastasis: differentiation from stomach and colorectal cancer.Japanese journal of radiology · 2025Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Secondary tumors of the ovary account for 10-25% of all ovarian malignancies. The most common tumors that give rise to ovarian metastases include breast, colorectal, endometrial, stomach, and appendix cancer. The correct diagnosis of secondary ovarian tumors may be challenging as they are not infrequently misdiagnosed as primary ovarian cancer, particularly in the case of mucinous adenocarcinomas. The distinction from the latter is essential, as it requires different treatment. Immunohistochemistry plays an important role in distinguishing primary ovarian tumors from extra-ovarian metastases and, furthermore, may suggest the primary tumor site. Despite extensive study, some cases remain equivocal even after assessing a broad spectrum of antigens. Therefore, gene expression profiling represents an approach able to further discriminate equivocal findings, and one that has been proven effective in determining the origin of cancer of unknown primary site. The available data concerning secondary ovarian tumors is rather limited owing to the relative heterogeneity of this group and the practical absence of any prospective trials. However, several intriguing questions are encountered in daily practice, including rational diagnostic workup, the role of cytoreductive surgery, and consequent adjuvant chemotherapy. This review seeks to address these issues comprehensively and summarize current knowledge on the epidemiology, pathogenesis, and management of secondary ovarian tumors, including further discussion on the different pathways of metastatisation, metastatic organotropism, and their possible molecular mechanisms.
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