ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2017
Aberrant cerebellar connectivity in bipolar disorder with psychosis.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 4 of them syntheses that pooled it.
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Who cites it
38 citing papers in PubMed, 4 syntheses or guidelines pooled it, 86 citations in OpenAlex.
- Transdiagnostic mapping of common and specific regional homogeneity alterations across affective and psychotic disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Pooled it
- Altered resting-state functional connectivity in bipolar disorder: a systematic review.Brain imaging and behavior · 2026Pooled it
- The Cerebellum in Frontotemporal Dementia: a Meta-Analysis of Neuroimaging Studies.Neuropsychology review · 2019Pooled it
- Multivariate meta-analyses of mitochondrial complex I and IV in major depressive disorder, bipolar disorder, schizophrenia, Alzheimer disease, and Parkinson disease.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Pooled it
- Regional cerebellar structural deficits distinguish psychostimulant-free ADHD youth with and without familial risk for bipolar I disorder: a cross-sectional morphometric analysis.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Cerebellar gray matter volume difference in first-episode bipolar and unipolar depression.BMC psychiatry · 2026Article
- Deletion of the Voltage-Gated Calcium Channel Gene, CaCerebellum (London, England) · 2025Article
- Investigating topological alterations in procedural memory network across neuropsychiatric disorders using rs-fMRI and graph theory.BMC neuroscience · 2025Article
- Predicting Mental and Neurological Illnesses Based on Cerebellar Normative Features.Biological psychiatry global open science · 2025Article
- Altered Brain-Behavior Association During Resting State is a Potential Psychosis Risk Marker.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Cerebellar and subcortical interplay in cognitive dysmetria: functional network signatures associate with symptom and trait assessments across schizophrenia, bipolar II, and ADHD patients.Brain imaging and behavior · 2025Article
- Reduced Cerebellar Volumes Associate with P300 Amplitude Attenuation in Children with Clinical High Risk for Psychosis and Early Onset Psychosis.Cerebellum (London, England) · 2025Article
- Cerebellar Effects on Abnormal Psychomotor Function Are Mediated by Processing Speed in Psychosis Spectrum.Cerebellum (London, England) · 2024Article
- Review
- A characteristic cerebellar biosignature for bipolar disorder, identified with fully automatic machine learning.IBRO neuroscience reports · 2023Article
- CaMKK2 as an emerging treatment target for bipolar disorder.Molecular psychiatry · 2023Review
- Cerebellar morphological differences and associations with extrinsic factors in bipolar disorder type I.Journal of affective disorders · 2023Article
- Review
- Resting-state functional connectivity of the cerebellum-cerebrum in older women with depressive symptoms.BMC psychiatry · 2023Article
- Supra-second interval timing in bipolar disorder: examining the role of disorder sub-type, mood, and medication status.International journal of bipolar disorders · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe cerebellum, which modulates affect and cognition in addition to motor functions, may contribute substantially to the pathophysiology of mood and psychotic disorders, such as bipolar disorder. A growing literature points to cerebellar abnormalities in bipolar disorder. However, no studies have investigated the topographic representations of resting state cerebellar networks in bipolar disorder, specifically their functional connectivity to cerebral cortical networks.
methodsUsing a well-defined cerebral cortical parcellation scheme as functional connectivity seeds, we compared ten cerebellar resting state networks in 49 patients with bipolar disorder and a lifetime history of psychotic features and 55 healthy control participants matched for age, sex, and image signal-to-noise ratio.
resultsPatients with psychotic bipolar disorder showed reduced cerebro-cerebellar functional connectivity in somatomotor A, ventral attention, salience, and frontoparietal control A and B networks relative to healthy control participants. These findings were not significantly correlated with current symptoms.
conclusionsPatients with psychotic bipolar disorder showed evidence of cerebro-cerebellar dysconnectivity in selective networks. These disease-related changes were substantial and not explained by medication exposure or substance use. Therefore, they may be mechanistically relevant to the underlying susceptibility to mood dysregulation and psychosis. Cerebellar mechanisms deserve further exploration in psychiatric conditions, and this study's findings may have value in guiding future studies on pathophysiology and treatment of mood and psychotic disorders, in particular.
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