ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2017
Tracking Deceased-Related Thinking with Neural Pattern Decoding of a Cortical-Basal Ganglia Circuit.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The neurobiological reward system in Prolonged Grief Disorder (PGD): A systematic review.Psychiatry research. Neuroimaging · 2020Pooled it
- Dwelling in prolonged grief: Resting state functional connectivity during oxytocin and placebo administration.Human brain mapping · 2023Trial
- Autonomic evidence that avoidance matters in the mourning process: A prospective observational study in Japan.Dialogues in clinical neuroscience · 2026Observational
- Prolonged grief disorder in later life: advancing our understanding of biopsychosocial mechanisms to guide future personalized interventions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- When perception meets grief: how the brain reconstructs person networks in response to absence.Social cognitive and affective neuroscience · 2025Article
- The nature of grief: implications for the neurobiology of emotion.Neuroscience of consciousness · 2024Article
- Ventral striatal subregional dysfunction in late-life grief: Relationships with yearning and depressive symptoms.Journal of psychiatric research · 2022Article
- A Short Functional Neuroimaging Assay Using Attachment Scenes to Recruit Neural Correlates of Social Cognition-A Replication Study.Brain sciences · 2022Article
- A Brain-Centric Model of Suicidal Behavior.The American journal of psychiatry · 2020Article
- Increased Amygdala Activations during the Emotional Experience of Death-Related Pictures in Complicated Grief: An fMRI Study.Journal of clinical medicine · 2020Article
- Self-generated Unconscious Processing of Loss Linked to Less Severe Grieving.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Article
- Ongoing monitoring of mindwandering in avoidant grief through cortico-basal-ganglia interactions.Social cognitive and affective neuroscience · 2019Article
Corrections and comments
- Commented on by
Authors and funding
7 authors.
Funding
Abstract
backgroundDeceased-related thinking is central to grieving and potentially critical to processing of the loss. Self-report measurements might fail to capture important elements of deceased-related thinking and processing. Here, we used a machine learning approach applied to fMRI - known as neural decoding - to develop a measure of ongoing deceased-related processing.
methods23 subjects grieving the loss of a first-degree relative, spouse or partner within 14 months underwent two fMRI tasks. They first viewed pictures and stories related to the deceased, a living control and a demographic control figure while providing ongoing valence and arousal ratings. Second, they performed a 10-minute Sustained Attention to Response Task (SART) with thought probes every 25-35 seconds to identify deceased, living and self-related thoughts.
resultsA conjunction analysis, controlling for valence/arousal, identified neural clusters in basal ganglia, orbital prefrontal cortex and insula associated with both types of deceased-related stimuli
conclusionsA neural pattern trained to identify mental representations of the deceased tracked deceased-related thinking during a sustained attention task and also predicted subject-level avoidance. This approach provides a new imaging tool to be used as an index of processing the deceased for future studies of complicated grief.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.