Evidence map›Paper›PMID 28730106›Full record

ArticleInternational journal of ophthalmology2017

Mitochondrial expression and activity of P-glycoprotein under oxidative stress in outer blood-retinal barrier.

Yue-Hong Zhang, Juan Li, Wei-Zhong Yang, Zhuan-Hua Xian, Qi-Ting Feng, Xiang-Cai Ruan

Open access · goldAbstract read
In one paragraph

Article in International journal of ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Regulation of P-Glycoprotein during Oxidative Stress.Antioxidants (Basel, Switzerland) · 2024
    Review
  2. Review
  3. Article
  4. Article
  5. Roles of Drug Transporters in Blood-Retinal Barrier.Advances in experimental medicine and biology · 2019
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yue-Hong ZhangDepartment of Ophthalmology, First Municipal People's Hospital of Guangzhou, Affiliated Hospital of Guangzhou Medical University, Guangzhou 510080, Guangdong Province, China.
Juan LiDepartment of Ophthalmology, Shaanxi Ophthalmic Medical Center, Xi'an No.4 Hospital, Affiliated Guangren Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China.
Wei-Zhong YangDepartment of Ophthalmology, First Municipal People's Hospital of Guangzhou, Affiliated Hospital of Guangzhou Medical University, Guangzhou 510080, Guangdong Province, China.
Zhuan-Hua XianDepartment of Ophthalmology, First Municipal People's Hospital of Guangzhou, Affiliated Hospital of Guangzhou Medical University, Guangzhou 510080, Guangdong Province, China.
Qi-Ting FengDepartment of Ophthalmology, First Municipal People's Hospital of Guangzhou, Affiliated Hospital of Guangzhou Medical University, Guangzhou 510080, Guangdong Province, China.
Xiang-Cai RuanDepartment of Anesthesiology, First Municipal People's Hospital of Guangzhou, Affiliated Hospital of Guangzhou Medical University, Guangzhou 510080, Guangdong Province, China.
Guangzhou Medical University · CNGuangzhou First People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the role of oxidative stress in regulating the functional expression of P-glycoprotein (P-gp) in mitochondria of D407 cells.

methodsD407 cells were exposed to different ranges of concentrations of H

resultsP-gp was co-localized in the mitochondria by confocal laser scanning microscopy, and it was also detected in the mitochondria of D407 cells using Western blot. Exposure to increasing concentrations of H

conclusionH

Indexed as

mitochondriaoxidative stressP-glycoproteinretinal pigment epithelium

Identifiers

PMID28730106
PMCPMC5514265
OpenAlexW2747071528

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.