ReviewWorld journal of nephrology2017
Causal relationship between hypoalbuminemia and acute kidney injury.
Review in World journal of nephrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 4 syntheses or guidelines pooled it, 117 citations in OpenAlex.
- Albumin levels in malaria patients: a systematic review and meta-analysis of their association with disease severity.Scientific reports · 2024Pooled it
- Association of Malnutrition with Risk of Acute Kidney Injury: A Systematic Review and Meta-Analysis.International journal of clinical practice · 2023Pooled it
- Pooled it
- The global incidence and mortality of contrast-associated acute kidney injury following coronary angiography: a meta-analysis of 1.2 million patients.Journal of nephrology · 2021Pooled it
- Naringenin protects against renal ischemia-reperfusion injury following unilateral nephrectomy via modulation of oxidative stress and kisspeptin expression.International urology and nephrology · 2026Article
- Determinants and Frequency of Acute Kidney Injury After Endoscopic Retrograde Cholangiopancreatography.Cureus · 2026Article
- Association of malnutrition with in-hospital outcomes among patients hospitalized with dermatomyositis or polymyositis.Clinical rheumatology · 2026Article
- Prenatal Benzydamine Exposure Induces Fetal Growth Restriction and Maternal Oxidative Stress in Rats.International journal of molecular sciences · 2026Article
- Preoperative serum albumin level is associated with postoperative short- and long-term renal function deterioration in patients who underwent radical cystectomy for bladder cancer.Investigative and clinical urology · 2026Article
- Association between uric acid to albumin ratio and all-cause mortality among United States adults: An observational study.Medicine · 2025Observational
- Creatinine Decline Rate as a Predictor of Renal Recovery After Acute Kidney Injury: A Retrospective Cohort Study.Diagnostics (Basel, Switzerland) · 2025Article
- Vancomycin-Induced Acute Kidney Injury in Intensive Care Patients: A Target Trial Emulation Study Using Multicenter Routinely Collected Data.Pharmacoepidemiology and drug safety · 2025Article
- A risk prediction model for acute kidney injury following acute heart failure in an emergency department cohort in China.World journal of emergency medicine · 2025Article
- Association of Albumin-to-D-Dimer Ratio with Mortality in Mechanically Ventilated Intensive Care Patients.Journal of clinical medicine · 2025Article
- The association of perioperative serum albumin concentrations with outcome after deceased donor liver transplantation.BMC anesthesiology · 2025Article
- Prediction of contrast-associated acute kidney injury with machine-learning in patients undergoing contrast-enhanced computed tomography in emergency department.Scientific reports · 2025Article
- Cancer diagnosis and prognosis after initiation of hemodialysis: multicenter Japan CANcer and DialYsis (J-CANDY) study.Clinical kidney journal · 2025Article
- Uric Acid to Albumin Ratio: A Predictive Marker for Acute Kidney Injury in Isolated Tricuspid Valve Surgery.Reviews in cardiovascular medicine · 2025Article
- Mice develop obesity and lose myocardial metabolic flexibility months after exertional heat stroke.Communications biology · 2025Article
- On-treatment serum albumin levels can predict 28-day mortality and guide albumin infusion in sepsis patients.Frontiers in medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our meta-analysis published in 2010 provided evidence that low levels of serum albumin (hypoalbuminemia) are a significant independent predictor of acute kidney injury (AKI) and death following AKI. Since then, a large volume of additional data from observational clinical studies has been published further evaluating the relationship between serum albumin and AKI occurrence. This is an updated review of the literature to re-evaluate the hypothesis that hypoalbuminemia is independently associated with increased AKI risk. Eligible studies published from September 2009 to December 2016 were sought in PubMed (MEDLINE) and forty-three were retained, the great majority being retrospective observational cohort studies. These included a total of about 68000 subjects across a diverse range of settings, predominantly cardiac surgery and acute coronary interventions, infectious diseases, transplant surgery, and cancer. Appraisal of this latest data set served to conclusively corroborate and confirm our earlier hypothesis that lower serum albumin is an independent predictor both of AKI and death after AKI, across a range of clinical scenarios. The body of evidence indicates that hypoalbuminemia may causally contribute to development of AKI. Furthermore, administration of human albumin solution has the potential to prevent AKI; a randomized, controlled study provides evidence that correcting hypoalbuminemia may be renal-protective. Therefore, measurement of serum albumin to diagnose hypoalbuminemia may help identify high-risk patients who may benefit from treatment with exogenous human albumin. Multi-center, prospective, randomized, interventional studies are warranted, along with basic research to define the mechanisms through which albumin affords nephroprotection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.