Evidence map›Paper›PMID 28729960›Full record

ArticleCureus2014

A Bioengineered Peptide that Localizes to and Illuminates Medulloblastoma: A New Tool with Potential for Fluorescence-Guided Surgical Resection.

Shelley E Ackerman, Christy M Wilson, Suzana A Kahn, James R Kintzing, Darren A Jindal, Samuel H Cheshier, Gerald A Grant, Jennifer R Cochran

Open access · diamondAbstract read
In one paragraph

Article in Cureus, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Shelley E AckermanBioengineering, Stanford University.
Christy M WilsonSchool of Medicine, Stanford University.
Suzana A KahnInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305.
James R KintzingDepartment of Bioengineering, Stanford University.
Darren A JindalDepartment of Bioengineering, Stanford University.
Samuel H CheshierDepartment of Neurosurgery and Neurology, Stanford University School of Medicine & Lucile Packard Children's Hospital, Department of Neurosurgery and Neurology, Stanford University School of Medicine & Lucile Packard Children's Hospital at Stanford.
Gerald A GrantDepartment of Neurosurgery, Stanford University School of Medicine.
Jennifer R CochranDepartment of Bioengineering and (by courtesy) Chemical Engineering, Stanford University.
Stanford University · USBioengineering Center · RU

Funding

Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI Melinda L. Telli · 2007 to 2026
$71.4M
Modulation of the Blood-Tumor Barrier Through Targeted Suppression of Claudin 5K08NS075144 · NINDS · STANFORD UNIVERSITY · PI GRANT, GERALD ARTHUR · 2011 to 2015
$641k
NCI NIH HHS P30 CA124435NINDS NIH HHS K08 NS075144
6 · The paper itself

Abstract

Tumors of the central nervous system are challenging to treat due to the limited effectiveness and associated toxicities of chemotherapy and radiation therapy. For tumors that can be removed surgically, extent of malignant tissue resection has been shown to correlate with disease progression, recurrence, and survival. Thus, improved technologies for real-time brain tumor imaging are critically needed as tools for guided surgical resection. We previously engineered a novel peptide that binds with high affinity and unique specificity to α

Indexed as

cystine-knot peptideengineered peptidefluorescence-guided surgical resectionGeneral Surgeryintegrinknottinmedulloblastomamolecular imagingNeurosurgeryOncologyprotein engineeringtumor targeting

Identifiers

PMID28729960
PMCPMC5515084
OpenAlexW2111603022

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.