ArticleBrain and behavior2017
Fatigue and cognition: Pupillary responses to problem-solving in early multiple sclerosis patients.
Article in Brain and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Assessment of visual contrast sensitivity in biotoxin-exposed individuals using four testing methods.Annals of medicine · 2026Article
- Eye-Tracking Metrics as a Digital Biomarker for Neurocognitive Disorders in Multiple Sclerosis: A Scoping Review.Brain sciences · 2025Review
- Basics, benefits, and pitfalls of pupillometers assessing visual function.Eye (London, England) · 2024Review
- The Role of Automated Infrared Pupillometry in Traumatic Brain Injury: A Narrative Review.Journal of clinical medicine · 2024Review
- Dynamic Pupillary Response in Multiple Sclerosis Patients with and without Optic Neuritis.Biomedicines · 2023Article
- Symptom Interconnectivity in Multiple Sclerosis: A Narrative Review of Potential Underlying Biological Disease Processes.Neurology and therapy · 2022Review
- Cognitive workload during verbal abstract reasoning in Parkinson's disease: a pilot study.The International journal of neuroscience · 2021Article
- Identifying Early Neuropsychological Indicators of Cognitive Involvement in Multiple Sclerosis.Neuropsychiatric disease and treatment · 2021Review
- Association of Electronic Health Record Use With Physician Fatigue and Efficiency.JAMA network open · 2020Article
- Functional-structural relationship in large-scale brain networks of patients with end stage renal disease after kidney transplantation: A longitudinal study.Human brain mapping · 2020Article
- The Potential Role of Neurophysiology in the Management of Multiple Sclerosis-Related Fatigue.Frontiers in neurology · 2020Review
- Autonomic symptom burden is an independent contributor to multiple sclerosis related fatigue.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2019Article
- Neurodegenerative Interplay of Cardiovascular Autonomic Dysregulation and the Retina in Early Multiple Sclerosis.Frontiers in neurology · 2019Article
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- Fatigue and cognition: Pupillary responses to problem-solving in early multiple sclerosis patients.Brain and behavior · 2017Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIn early multiple sclerosis (MS) patients, cognitive changes and fatigue are frequent and troublesome symptoms, probably related to both structural and functional brain changes. Whether there is a common cause of these symptoms in MS is unknown. In theory, an altered regulation of central neuropeptides can lead to changes in regulation of autonomic function, cognitive difficulties, and fatigue. Direct measurements of central neuropeptides are difficult to perform, but measurements of the eye pupil can be used as a reliable proxy of function.
methodsThis study assesses pupil size during problem-solving in early MS patients versus controls. A difference in pupil size to a cognitive challenge could signal altered activity within the autonomic system because of early functional brain changes associated with cognitive load. We recruited MS patients (mean disease duration: 2.6 years,
resultsBoth groups performed well on the cognitive test. The groups showed similar pupillary responses with a mean of 0.55 mm dilation in patients and 0.54 mm dilation in controls for all the tasks collapsed together. However, controls (
conclusionsThis is the first study to investigate pupillary responses to cognitive tasks in MS patients. Our results suggest that MS-related changes in cognition and fatigue may be associated with changes in arousal and the autonomic regulation of task-related pupillary responses. This supports the theory of a link between cognition and fatigue in MS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.