ArticleBrain and behavior2017
Coherence of BOLD signal and electrical activity in the human brain during deep sevoflurane anesthesia.
Article in Brain and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Comprehensive profiling of brain dynamics during anesthesia across phylogeny.Nature neuroscience · 2026Article
- General anaesthesia decreases the uniqueness of brain functional connectivity across individuals and species.Nature human behaviour · 2025Article
- Total cerebral blood volume changes drive macroscopic cerebrospinal fluid flux in humans.PLoS biology · 2025Article
- An anesthetic protocol for preserving functional network structure in the marmoset monkey brain.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Characteristic dynamic functional connectivity during sevoflurane-induced general anesthesia.Scientific reports · 2023Article
- General anaesthesia reduces the uniqueness of brain connectivity across individuals and across species.bioRxiv : the preprint server for biology · 2023Article
- The effect of burst suppression on cerebral blood flow and autoregulation: a scoping review of the human and animal literature.Frontiers in physiology · 2023Article
- Spatial signatures of anesthesia-induced burst-suppression differ between primates and rodents.eLife · 2022Article
- Predicting Individual Treatment Response to rTMS for Motor Recovery After Stroke: A Review and the CanStim Perspective.Frontiers in rehabilitation sciences · 2022Review
- Brain network integration dynamics are associated with loss and recovery of consciousness induced by sevoflurane.Human brain mapping · 2021Article
- Random Forest Classification of Alcohol Use Disorder Using EEG Source Functional Connectivity, Neuropsychological Functioning, and Impulsivity Measures.Behavioral sciences (Basel, Switzerland) · 2020Article
- The (Un)Conscious Mouse as a Model for Human Brain Functions: Key Principles of Anesthesia and Their Impact on Translational Neuroimaging.Frontiers in systems neuroscience · 2020Review
- Permutation entropy in intraoperative ECoG of brain tumour patients in awake tumour surgery- a robust parameter to separate consciousness from unconsciousness.Scientific reports · 2019Article
- Comparison of the Effects of Desflurane and Sevoflurane on Cerebral Oxygen Saturation in Patients Undergoing Thyroidectomy: A Randomised Controlled Clinical Study.Turkish journal of anaesthesiology and reanimation · 2019Article
- Isoflurane-Induced Burst Suppression Increases Intrinsic Functional Connectivity of the Monkey Brain.Frontiers in neuroscience · 2019Article
- Prominent Changes in Cerebro-Cerebellar Functional Connectivity During Continuous Cognitive Processing.Frontiers in cellular neuroscience · 2018Article
- Human neural correlates of sevoflurane-induced unconsciousness.British journal of anaesthesia · 2017Review
- Coherence of BOLD signal and electrical activity in the human brain during deep sevoflurane anesthesia.Brain and behavior · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionChanges in neural activity induce changes in functional magnetic resonance (fMRI) blood oxygenation level dependent (BOLD) signal. Commonly, increases in BOLD signal are ascribed to cellular excitation.
objectiveThe relationship between electrical activity and BOLD signal in the human brain was probed on the basis of burst suppression EEG. This condition includes two distinct states of high and low electrical activity.
methodsResting-state simultaneous EEG and BOLD measurements were acquired during deep sevoflurane anesthesia with burst suppression EEG in nineteen healthy volunteers. Afterwards, fMRI volumes were assigned to one of the two states (burst or suppression) as defined by the EEG.
resultsIn the frontal, parietal and temporal lobes as well as in the basal ganglia, BOLD signal increased after burst onset in the EEG and decreased after onset of EEG suppression. In contrast, BOLD signal in the occipital lobe was anticorrelated to electrical activity. This finding was obtained consistently in a general linear model and in raw data.
conclusionsIn human brains exhibiting burst suppression EEG induced by sevoflurane, the positive correlation between BOLD signal and electrical brain activity could be confirmed in most gray matter. The exceptional behavior of the occipital lobe with an anticorrelation of BOLD signal and electrical activity might be due to specific neurovascular coupling mechanisms that are pronounced in the deeply anesthetized brain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.