Evidence map›Paper›PMID 28729719›Full record

ArticleScientific reports2017

Inhibition of TGF-β signaling supports high proliferative potential of diverse p63

Daisuke Suzuki, Filipa Pinto, Makoto Senoo

Abstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Daisuke SuzukiDepartment of Molecular and Cell Biology, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, 02118, USA.
Filipa PintoDepartment of Molecular and Cell Biology, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, 02118, USA.
Makoto SenooDepartment of Molecular and Cell Biology, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, 02118, USA. msenoo@bu.edu.ORCID 0000-0002-0155-0683

Funding

Intrinsic and extrinsic regulation of epidermal stem cellsR01AR066755 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI SENOO, MAKOTO · 2014 to 2018
$1.8M
NIAMS NIH HHS R01 AR066755
6 · The paper itself

Abstract

Mouse models have been used to provide primary cells to study physiology and pathogenesis of epithelia. However, highly efficient simple approaches to propagate mouse primary epithelial cells remain challenging. Here, we show that pharmacological inhibition of TGF-β signaling enables long-term expansion of p63

Indexed as

Signal TransductionAnimalsCell DifferentiationCell LineCell ProliferationCell Self RenewalEpidermal CellsEpithelial CellsMicePhosphoproteinsStem CellsTrans-ActivatorsTransforming Growth Factor betaPhosphoproteinsTrans-ActivatorsTransforming Growth Factor betaTrp63 protein, mouse

Identifiers

PMID28729719
PMCPMC5519764

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.