ArticleScientific reports2017
Structure of general-population antibody titer distributions to influenza A virus.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Evidence of previous but not current transmission of chikungunya virus in southern and central Vietnam: Results from a systematic review and a seroprevalence study in four locations.PLoS neglected tropical diseases · 2018Pooled it
- Measuring population immunity against influenza using individual antibody titres: a multicountry, retrospective observational study.The Lancet. Infectious diseases · 2026Observational
- Spatial variation in risk factors for anti-hepatitis E antibody titers in a population-based German study.Scientific reports · 2025Article
- Article
- Estimating the force of infection of four dengue serotypes from serological studies in two regions of Vietnam.PLoS neglected tropical diseases · 2024Article
- Age-dependent heterogeneity in the antigenic effects of mutations to influenza hemagglutinin.Cell host & microbe · 2024Article
- Age-time-specific transmission of hand-foot-and-mouth disease enterovirus serotypes in Vietnam: A catalytic model with maternal immunity.Epidemics · 2024Article
- Age-dependent heterogeneity in the antigenic effects of mutations to influenza hemagglutinin.bioRxiv : the preprint server for biology · 2023Article
- A combination of annual and nonannual forces drive respiratory disease in the tropics.BMJ global health · 2023Article
- A combination of annual and nonannual forces drive respiratory disease in the tropics.medRxiv : the preprint server for health sciences · 2023Article
- Seroprotection against tetanus in southern Vietnam.Vaccine · 2023Article
- Estimating dengue transmission intensity from serological data: A comparative analysis using mixture and catalytic models.PLoS neglected tropical diseases · 2022Article
- SARS-CoV-2 epidemic after social and economic reopening in three U.S. states reveals shifts in age structure and clinical characteristics.Science advances · 2022Article
- Age-seroprevalence curves for the multi-strain structure of influenza A virus.Nature communications · 2021Article
- Herpesviruses Serology Distinguishes Different Subgroups of Patients From the United Kingdom Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Biobank.Frontiers in medicine · 2021Article
- Rapid generation of durable B cell memory to SARS-CoV-2 spike and nucleocapsid proteins in COVID-19 and convalescence.Science immunology · 2020Article
- Plans for Nationwide Serosurveillance Network in Vietnam.Emerging infectious diseases · 2020Article
- Serological inference of past primary and secondary dengue infection: implications for vaccination.Journal of the Royal Society, Interface · 2019Article
- Hepatitis E in southern Vietnam: Seroepidemiology in humans and molecular epidemiology in pigs.Zoonoses and public health · 2018Article
Corrections and comments
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Authors and funding
23 authors at 8 institutions in 5 countries.
Funding
Abstract
Seroepidemiological studies aim to understand population-level exposure and immunity to infectious diseases. Their results are normally presented as binary outcomes describing the presence or absence of pathogen-specific antibody, despite the fact that many assays measure continuous quantities. A population's natural distribution of antibody titers to an endemic infectious disease may include information on multiple serological states - naiveté, recent infection, non-recent infection, childhood infection - depending on the disease in question and the acquisition and waning patterns of immunity. In this study, we investigate 20,152 general-population serum samples from southern Vietnam collected between 2009 and 2013 from which we report antibody titers to the influenza virus HA1 protein using a continuous titer measurement from a protein microarray assay. We describe the distributions of antibody titers to subtypes 2009 H1N1 and H3N2. Using a model selection approach to fit mixture distributions, we show that 2009 H1N1 antibody titers fall into four titer subgroups and that H3N2 titers fall into three subgroups. For H1N1, our interpretation is that the two highest-titer subgroups correspond to recent and historical infection, which is consistent with 2009 pandemic attack rates. Similar interpretations are available for H3N2, but right-censoring of titers makes these interpretations difficult to validate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.