ArticleScientific reports2017
Engineering Tumour Cell-Binding Synthetic Polymers with Sensing Dense Transporters Associated with Aberrant Glutamine Metabolism.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 24 citations in OpenAlex.
- Surface Avidity of Anionic Polypeptide Coatings on Layer-by-Layer Nanoparticles Target Cancer-Associated Amino Acid Transporters.Angewandte Chemie (International ed. in English) · 2026Article
- Engineering micelles with hydrophilic-lipophilic balance to overcome intestinal barrier for oral therapeutic application.Materials today. Bio · 2025Article
- Review
- Zwitterionic Amino-Acid-Derived Polyacrylamides with a Betaine Twist - Synthesis and Characterization.Macromolecular rapid communications · 2025Article
- Impact of the polymer backbone chemistry on interactions of amino-acid-derived zwitterionic polymers with cells.Bioactive materials · 2023Article
- Poly(vinyl alcohol) boosting therapeutic potential ofScience advances · 2020Article
- LAT1-Targeting Thermoresponsive Fluorescent Polymer Probes for Cancer Cell Imaging.International journal of molecular sciences · 2018Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increased glutamine uptake toward the elevated glutaminolysis is one of the hallmarks of tumour cells. This aberrant glutamine metabolism has recently attracted considerable attention as a diagnostic and therapeutic target. Herein, we developed glutamine-functionalized polymer to achieve a selective high affinity to tumour cells overexpressing glutaminolysis-related transporter ASCT2. In in vitro study, our developed polymer exhibited faster and higher cellular uptake in tumour cells than that in normal cells. Uptake inhibition study revealed the dominant contribution of ASCT2 to the polymer-cell interaction. Furthermore, the binding affinity of the polymer to tumour cells was estimated to be comparable to that of the potent ligand molecules reported in the literature. In in vivo study, the polymer showed prolonged retention at tumour site after intratumoral injection. This study offers a novel approach for designing tumour cell-binding synthetic polymers through the recognition of dense transporters related to tumour-associated metabolism.
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