ArticleScientific reports2017
Knockdown of two Cadherin genes confers resistance to Cry2A and Cry1C in Chilo suppressalis.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Review
- ARGOS homolog evolution in brassicaceae and the role of BnaC6.ARGOS in conferring drought tolerance via expression-responsive localization and reduced seed porosity in rapeseed.BMC plant biology · 2025Article
- Mismatch between lab-generated and field-evolved resistance to transgenic Bt crops inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Utilization of Diverse Molecules as Receptors by Cry Toxin and the Promiscuous Nature of Receptor-Binding Sites Which Accounts for the Diversity.Biomolecules · 2024Review
- Cadherin Is a Binding Protein but Not a Functional Receptor of Bacillus thuringiensis Cry2Ab in Helicoverpa armigera.Applied and environmental microbiology · 2023Article
- Analysis of the Genetic Stability of Insect and Herbicide Resistance Genes in Transgenic Rice Lines: A Laboratory and Field Experiment.Rice (New York, N.Y.) · 2023Article
- Comparison of the Phenotypic Performance, Molecular Diversity, and Proteomics in Transgenic Rice.Plants (Basel, Switzerland) · 2022Article
- Genome evolution in an agricultural pest following adoption of transgenic crops.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Bacillus thuringiensis Cry1Ab Domain III β-16 Is Involved in Binding to Prohibitin, Which Correlates with Toxicity against Helicoverpa armigera (Lepidoptera: Noctuidae).Applied and environmental microbiology · 2021Article
- Differences in midgut transcriptomes between resistant and susceptible strains of Chilo suppressalis to Cry1C toxin.BMC genomics · 2020Article
- Mutations in a Novel Cadherin Gene Associated with Bt Resistance inG3 (Bethesda, Md.) · 2020Article
- Cadherin CsCad plays differential functional roles in Cry1Ab and Cry1C intoxication in Chilo suppressalis.Scientific reports · 2019Article
- Recent progress on the interaction between insects and Bacillus thuringiensis crops.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacillus thuringiensis (Bt) Cry toxins play an important role in the management of insect pests. Resistance to Bt toxins has been reported in many pest insects but the mechanism responsible for this resistance in rice crop pests remains largely unknown. Cadherin is one of several Bt toxin receptors. At present, only one cadherin gene, CsCAD1, has been documented in the striped rice stem borer, Chilo suppressalis. We amplified a nearly full-length transcript of another C. suppressalis cadherin gene, CsCAD2, and found that it has a different expression pattern to CsCAD1. CsCAD1 was highly expressed in fifth and sixth instar larvae, especially in the midgut, while the expression levels of CsCA2 were equably in each developmental stage. Newly hatched larvae were fed on rice smeared with synthesized siRNA to knockdown either CsCAD1 or CsCAD2, and then were fed transgenic rice expressing either the Cry2A or Cry1C toxins. The siRNA-treatment groups had lower mortality and higher survival rates than the control group, suggesting that reduced expression of CsCAD1 or CsCAD2 increased resistance to Cry2A and Cry1C. We conclude that CsCAD1 and CsCAD2 interact with Bt toxins in C. suppressalis and that this interaction could be the mechanism underlying Bt resistance in this insect.
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