Evidence map›Paper›PMID 28729608›Full record

ArticleScientific reports2017

Programmed death one homolog maintains the pool size of regulatory T cells by promoting their differentiation and stability.

Qi Wang, Jianwei He, Dallas B Flies, Liqun Luo, Lieping Chen

Erratum issuedAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Review
  2. Article
  3. Leveraging T cells for cancer immunotherapy.Immunity & inflammation · 2025
    Review
  4. Review
  5. VISTA-mediated immune evasion in cancer.Experimental & molecular medicine · 2024
    Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Exploring the VISTA of microglia: immune checkpoints in CNS inflammation.Journal of molecular medicine (Berlin, Germany) · 2020
    Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Qi WangLaboratory of Immunotherapy, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China.
Jianwei HeLaboratory of Immunotherapy, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China.
Dallas B FliesDepartment of Immunobiology, Yale University, New Haven, Connecticut, USA.
Liqun LuoLaboratory of Immunotherapy, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China.
Lieping ChenLaboratory of Immunotherapy, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China. Lieping.Chen@yale.edu.

Funding

Yale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI MARCUS W BOSENBERG · 1985 to 2026
$85.0M
Yale SPORE in Lung Cancer (YSILC): The Biology and Personalized Treatment of Lung CancerP50CA196530 · NCI · YALE UNIVERSITY · PI Kurt A Schalper · 2015 to 2026
$31.1M
NCI NIH HHS P30 CA016359NCI NIH HHS P50 CA196530
6 · The paper itself

Abstract

Programmed death one homolog (PD-1H) is an immunoglobulin superfamily molecule and primarily acts as a coinhibitor in the initiation of T cell response to antigens. Here, we report that genetic ablation of PD-1H in mice blocks the differentiation of naive T cells to Foxp3

Indexed as

AnimalsApoptosisBiomarkersCell DifferentiationCytokinesEnhancer Elements, GeneticForkhead Transcription FactorsImmune ToleranceInflammation MediatorsMembrane ProteinsMethylationMiceMice, KnockoutSTAT3 Transcription FactorTh17 CellsT-Lymphocytes, RegulatoryBiomarkersCytokinesForkhead Transcription FactorsFoxp3 protein, mouseInflammation MediatorsMembrane ProteinsSTAT3 Transcription FactorVsir protein, mouse

Identifiers

PMID28729608
PMCPMC5519767

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.