ArticleNature communications2017
Early-life disruption of amphibian microbiota decreases later-life resistance to parasites.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
84 citing papers in PubMed, 197 citations in OpenAlex.
- Residual yolk depletion matches the establishment of functional oral-intestinal microbiota in hatchling Siamese crocodiles.iScience · 2026Article
- Effects of Timing of Microbial Exposure on Microbiome Assembly and Amphibian Immune Development.Ecology and evolution · 2026Article
- Age at First Reproduction Predicts Sex-Specific Parasite Infection Trajectories Through Adulthood.Ecology and evolution · 2026Article
- Exposure to Environmental Microbes Alters Responsiveness of Tadpole Gut Microbiome to Dietary Tannins.Integrative zoology · 2026Article
- Differential Immune Responses Correlate With Chytridiomycosis Severity in Italian Crested Newts.Molecular ecology · 2026Article
- Integrating the Microbiome Into Infection Ecology and Evolution in Wild Animals.Molecular ecology · 2026Review
- Stochasticity Prevails but Differs: Tissue-Specific Assembly of Gut Microbiomes Across Seasons in an Amphibian Model.Ecology and evolution · 2026Article
- The versatility ofAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
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- Exposure to Rice Straw Ash Alters Survival, Development and Microbial Diversity in Amphibian Tadpoles.Ecology and evolution · 2025Article
- Reorganization of bacterial community network structure in the eastern redback salamander (Plethodon cinereus) and its soil reservoir across a gradient of land use.FEMS microbiology ecology · 2025Article
- Triclocarban exposure at environmentally relevant concentrations perturbs the gut microbiota and metabolic profile inFrontiers in microbiology · 2025Article
- 'Re-Wilding' an Animal Model With Microbiota Shifts Immunity and Stress Gene Expression During Infection.Molecular ecology · 2025Article
- The impact of microbiome diversity and composition on host health and susceptibility to disease across amphibian life stages.Frontiers in amphibian and reptile science · 2025Article
- Social, environmental, and developmental factors affect the microbiota of barn owls (Tyto alba) in a cross-fostering experiment.Animal microbiome · 2024Article
- Skin Bacterial and Fungal Microbiome Responses to Diet Supplementation and Rewilding in the Critically Endangered Southern Corroboree Frog.Molecular ecology · 2024Article
- Manipulating a host-native microbial strain compensates for low microbial diversity by increasing weight gain in a wild bird population.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Quantitative Synthesis of Microbe-Driven Acclimation and Adaptation in Wild Vertebrates.Evolutionary applications · 2024Review
- The microbiome at the interface between environmental stress and animal health: an example from the most threatened vertebrate group.Proceedings. Biological sciences · 2024Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Changes in the early-life microbiota of hosts might affect infectious disease risk throughout life, if such disruptions during formative times alter immune system development. Here, we test whether an early-life disruption of host-associated microbiota affects later-life resistance to infections by manipulating the microbiota of tadpoles and challenging them with parasitic gut worms as adults. We find that tadpole bacterial diversity is negatively correlated with parasite establishment in adult frogs: adult frogs that had reduced bacterial diversity as tadpoles have three times more worms than adults without their microbiota manipulated as tadpoles. In contrast, adult bacterial diversity during parasite exposure is not correlated with parasite establishment in adult frogs. Thus, in this experimental setup, an early-life disruption of the microbiota has lasting reductions on host resistance to infections, which is possibly mediated by its effects on immune system development. Our results support the idea that preventing early-life disruption of host-associated microbiota might confer protection against diseases later in life.Early-life microbiota alterations can affect infection susceptibility later in life, in animal models. Here, Knutie et al. show that manipulating the microbiota of tadpoles leads to increased susceptibility to parasitic infection in adult frogs, in the absence of substantial changes in the adults' microbiota.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.