ArticleScientific reports2017
Evaluation of ATM heterozygous mutations underlying individual differences in radiosensitivity using genome editing in human cultured cells.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Pathophysiological significance of cholesterol in ciliopathies.Fujita medical journal · 2026Article
- Cholesterol ensures ciliary polycystin-2 localization to prevent polycystic kidney disease.Life science alliance · 2025Article
- Differential Distribution of the DNA-PKcs Inhibitor Peposertib Selectively Radiosensitizes Patient-derived Melanoma Brain Metastasis Xenografts.Molecular cancer therapeutics · 2024Article
- Review
- Prospects of circular RNAs: the regulators of drug resistance and metastasis in gastric cancer.American journal of translational research · 2022Review
- NBS1 I171V variant underlies individual differences in chromosomal radiosensitivity within human populations.Scientific reports · 2021Article
- Ciliary GPCR-based transcriptome as a key regulator of cilia length control.FASEB bioAdvances · 2021Article
- Double Heterozygous Mutations in theBreast care (Basel, Switzerland) · 2021Article
- Insufficiency of ciliary cholesterol in hereditary Zellweger syndrome.The EMBO journal · 2020Article
- Space Radiation Biology for "Living in Space".BioMed research international · 2020Review
- The identification of key genes in nasopharyngeal carcinoma by bioinformatics analysis of high-throughput data.Molecular biology reports · 2019Article
- Exploration of genetic basis underlying individual differences in radiosensitivity within human populations using genome editing technology.Journal of radiation research · 2018Review
- Updated summary of genome editing technology in human cultured cells linked to human genetics studies.Journal of human genetics · 2018Review
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ionizing radiation (IR) induces DNA double-strand breaks (DSBs), which are an initial step towards chromosomal aberrations and cell death. It has been suggested that there are individual differences in radiosensitivity within human populations, and that the variations in DNA repair genes might determine this heterogeneity. However, it is difficult to quantify the effect of genetic variants on the individual differences in radiosensitivity, since confounding factors such as smoking and the diverse genetic backgrounds within human populations affect radiosensitivity. To precisely quantify the effect of a genetic variation on radiosensitivity, we here used the CRISPR-ObLiGaRe (Obligate Ligation-Gated Recombination) method combined with the CRISPR/Cas9 system and a nonhomologous end joining (NHEJ)-mediated knock-in technique in human cultured cells with a uniform genetic background. We generated ATM heterozygous knock-out (ATM
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