Evidence map›Paper›PMID 28729533›Full record

ArticleScientific reports2017

Common Brain Structure Findings Across Children with Varied Reading Disability Profiles.

Mark A Eckert, Kenneth I Vaden, Amanda B Maxwell, Stephanie L Cute, Mulugeta Gebregziabher, Virginia W Berninger, Dyslexia Data Consortium

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Structural Brain Correlates of Poor Reading Comprehension.Neurobiology of language (Cambridge, Mass.) · 2026
    Article
  2. Article
  3. Review
  4. Dyslexia Data Consortium Repository: A Data Sharing and Delivery Platform for Research.Brain informatics : 16th International Conference, BI 2023, Hoboken, NJ, USA, August 1-3, 2023, Proceedings. International Conference on Brain Informatics (16th : 2023 : Hoboken, N.J.) · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. A pericallosal lipoma case with evidence of surface dyslexia.Cortex; a journal devoted to the study of the nervous system and behavior · 2019
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 20 institutions in 6 countries.

Mark A EckertDepartment of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, SC, 29425, USA. eckert@musc.edu.
Kenneth I VadenDepartment of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, SC, 29425, USA.
Amanda B MaxwellDepartment of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, SC, 29425, USA.
Stephanie L CuteKennedy Krieger Institute, Baltimore, MD, 21205, USA.
Mulugeta GebregziabherDepartment of Public Health Sciences, Medical University of South Carolina, Charleston, SC, 29425, USA.
Virginia W BerningerDepartment of Educational Psychology, University of Washington, Seattle, WA, 98105, USA.
Dyslexia Data Consortium
Medical University of South Carolina · USStanford University · USUniversity of Washington · USAmerican Academy of Child and Adolescent Psychiatry · USArkansas Children's Hospital · USAston University · GBGeorgetown University · USHaskins Laboratories · USInserm · FRKennedy Krieger Institute · USMax Planck Institute for Human Cognitive and Brain Sciences · DEMiddle Tennessee State University · USNew York University · USSouthern Illinois University Carbondale · USThe University of Texas Southwestern Medical Center · USUniversity of Alberta · CAUniversity of British Columbia · CAUniversity of California, Merced · USUniversity of California, Riverside · USUniversity of California, San Francisco · US

Funding

Services Core P50HD071764 · NICHD · UNIVERSITY OF WASHINGTON · PI BERNINGER, VIRGINIA WISE · 2012 to 2016
$8.0M
Multi-site Study of DyslexiaR01HD069374 · NICHD · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Mark Andrew Eckert · 2012 to 2026
$4.3M
RENOVATION TO SUPPORT SENSORY NEUROSCIENCE RESEARCHC06RR014516 · NCRR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI RAYMOND, JOHN R · 1999 to 1999
–
NCRR NIH HHS C06 RR014516NICHD NIH HHS P50 HD071764NICHD NIH HHS R01 HD069374
6 · The paper itself

Abstract

Dyslexia is a developmental disorder in reading that exhibits varied patterns of expression across children. Here we examined the degree to which different kinds of reading disabilities (defined as profiles or patterns of reading problems) contribute to brain morphology results in Jacobian determinant images that represent local brain shape and volume. A matched-pair brain morphometry approach was used to control for confounding from brain size and research site effects in this retrospective multi-site study of 134 children from eight different research sites. Parietal operculum, corona radiata, and internal capsule differences between cases and controls were consistently observed across children with evidence of classic dyslexia, specific comprehension deficit, and language learning disability. Thus, there can be common brain morphology findings across children with quite varied reading disability profiles that we hypothesize compound the developmental difficulties of children with unique reading disability profiles and reasons for their reading disability.

Indexed as

NeuroimagingBrainBrain MappingCase-Control StudiesChildDyslexiaFemaleHumansImage Processing, Computer-AssistedMale

Identifiers

PMID28729533
PMCPMC5519686
OpenAlexW2735159654

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.