Evidence map›Paper›PMID 28729419›Full record

ArticleThe Journal of biological chemistry2017

The exocyst is required for photoreceptor ciliogenesis and retinal development.

Glenn P Lobo, Diana Fulmer, Lilong Guo, Xiaofeng Zuo, Yujing Dang, Seok-Hyung Kim, Yanhui Su, Kola George, Elisabeth Obert, Ben Fogelgren and 4 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. The exocyst in ciliogenesis.Renal failure · 2025
    Review
  3. Article
  4. Intracellular and Extracellular Vesicle miRNA Signatures in Human iPSC-Derived Neural Stem Cells and Floor Plate Progenitors.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Functional compartmentalization of photoreceptor neurons.Pflugers Archiv : European journal of physiology · 2021
    Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Glenn P LoboFrom the Departments of Medicine.
Diana FulmerFrom the Departments of Medicine.
Lilong GuoFrom the Departments of Medicine.
Xiaofeng ZuoFrom the Departments of Medicine.
Yujing DangFrom the Departments of Medicine.
Seok-Hyung KimFrom the Departments of Medicine.
Yanhui SuFrom the Departments of Medicine.
Kola GeorgeFrom the Departments of Medicine.
Elisabeth ObertOphthalmology, and.
Ben Fogelgrenthe Department of Anatomy, Biochemistry, and Physiology, University of Hawaii at Manoa, Honolulu, Hawaii 96813.
Deepak NihalaniFrom the Departments of Medicine.
Russell A NorrisRegenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, South Carolina 29425.
Bärbel RohrerOphthalmology, and.
Joshua H LipschutzFrom the Departments of Medicine, lipschut@musc.edu.
Medical University of South Carolina · USOphthalmology Associates (United States) · USRalph H. Johnson VA Medical Center · USUniversity of Hawaiʻi at Mānoa · US

Funding

UAB Recessive PKD Research and Translational Core CenterP30DK074038 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YODER, BRADLEY K. · 2005 to 2019
$16.6M
Targeted Nano-therapeutics for Neural RegenerationP20GM103444 · NIGMS · CLEMSON UNIVERSITY · PI MARKWALD, ROGER R, VYAVAHARE, NAREN R · 2012 to 2018
$14.9M
Transgenic Mouse, ICSI and IVF CoreP20GM103457 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI URSCHITZ, JOHANN · 2012 to 2018
$12.9M
Cilia and Valvular Heart DiseaseR01HL131546 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI NORRIS, RUSSELL · 2016 to 2025
$4.4M
Myo1c Participates in Podocyte Junction Formation Through Interaction with Neph1R01DK087956 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI NIHALANI, DEEPAK · 2010 to 2018
$3.5M
Genetics and Mechanisms of Mitral Valve ProlapseR01HL127692 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MILAN, DAVID J, SLAUGENHAUPT, SUSAN A · 2015 to 2018
$3.0M
ECT Implants for Factor H Delivery in Models of AMDR01EY024581 · NEI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ROHRER, BAERBEL · 2014 to 2016
$1.1M
The exocyst in kidney development and cyst formationK01DK087852 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI FOGELGREN, BENJAMIN C. · 2010 to 2014
$764k
Physiological Role of the Zebrafish Retinol Receptor rbpr2 in VisionR21EY025034 · NEI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI LOBO, GLENN P · 2015 to 2016
$436k
Complement Factor H Haplotypes and Smoking in Age-Related Macular DegenerationI01RX000444 · VA · RALPH H JOHNSON VA MEDICAL CENTER · PI Baerbel Rohrer · 2011 to 2026
–
The exocyst in ciliogenesis and cystogenesisI01BX000820 · VA · RALPH H JOHNSON VA MEDICAL CENTER · PI JOSHUA H LIPSCHUTZ · 2011 to 2026
–
BLRD VA I01 BX000820NEI NIH HHS R01 EY024581NEI NIH HHS R21 EY025034NHLBI NIH HHS R01 HL127692NHLBI NIH HHS R01 HL131546NIDDK NIH HHS K01 DK087852NIDDK NIH HHS P30 DK074038NIDDK NIH HHS R01 DK087956NIGMS NIH HHS P20 GM103444NIGMS NIH HHS P20 GM103457RRD VA I01 RX000444
6 · The paper itself

Abstract

We previously have shown that the highly conserved eight-protein exocyst trafficking complex is required for ciliogenesis in kidney tubule cells. We hypothesized here that ciliogenic programs are conserved across organs and species. To determine whether renal primary ciliogenic programs are conserved in the eye, and to characterize the function and mechanisms by which the exocyst regulates eye development in zebrafish, we focused on

Indexed as

ExocytosisAnimalsCiliaMiceMice, Inbred C57BLMutationPhotoreceptor Cells, VertebrateRetinaVesicular Transport ProteinsZebrafishEXOC5 protein, mouseVesicular Transport Proteinsexocystexocytosiseyephotoreceptorprimary ciliumretinal degeneration

Identifiers

PMID28729419
PMCPMC5592663
OpenAlexW2738984530

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.