ArticleCancer research2017
Mathematical Modeling of Tumor-Tumor Distant Interactions Supports a Systemic Control of Tumor Growth.
Article in Cancer research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 48 citations in OpenAlex.
- Gompertz growth with a shared carrying capacity optimally simulates primary and metastatic tumor growth dynamics.British journal of cancer · 2026Article
- Mathematical modeling of the effect of early detection in breast cancer treatment.Frontiers in oncology · 2025Article
- Practical parameter identifiability and handling of censored data with Bayesian inference in mathematical tumour models.NPJ systems biology and applications · 2024Article
- A multiscale model of the role of microenvironmental factors in cell segregation and heterogeneity in breast cancer development.PLoS computational biology · 2023Article
- Integrated computational and in vivo models reveal Key Insights into macrophage behavior during bone healing.PLoS computational biology · 2022Article
- Modeling the effects of EMT-immune dynamics on carcinoma disease progression.Communications biology · 2021Article
- Quantitative Systems Pharmacology Approaches for Immuno-Oncology: Adding Virtual Patients to the Development Paradigm.Clinical pharmacology and therapeutics · 2021Review
- Implications of immune-mediated metastatic growth on metastatic dormancy, blow-up, early detection, and treatment.Journal of mathematical biology · 2020Article
- The initial engraftment of tumor cells is critical for the future growth pattern: a mathematical study based on simulations and animal experiments.BMC cancer · 2020Article
- Brain Metastases: Insights from Statistical Modeling of Size Distribution.AJNR. American journal of neuroradiology · 2020Article
- Metastasis Initiation Precedes Detection of Primary Cancer-Analysis of Metastasis GrowthFrontiers in physiology · 2020Article
- Lessons from Hippocrates: Time to Change the Cancer Paradigm.International journal of chronic diseases · 2020Review
- Quantitative mathematical modeling of clinical brain metastasis dynamics in non-small cell lung cancer.Scientific reports · 2019Article
- Article
- Immunologic Consequences of Sequencing Cancer Radiotherapy and Surgery.JCO clinical cancer informatics · 2019Article
- Illuminating the Numbers: Integrating Mathematical Models to Optimize Photomedicine Dosimetry and Combination Therapies.Frontiers in physics · 2019Article
- Investigation of tumor-tumor interactions in a double human cervical carcinoma xenograft model in nude mice.Oncotarget · 2018Article
- Dose- and time-dependence of the host-mediated response to paclitaxel therapy: a mathematical modeling approach.Oncotarget · 2018Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Interactions between different tumors within the same organism have major clinical implications, especially in the context of surgery and metastatic disease. Three main explanatory theories (competition, angiogenesis inhibition, and proliferation inhibition) have been proposed, but precise determinants of the phenomenon remain poorly understood. Here, we formalized these theories into mathematical models and performed biological experiments to test them with empirical data. In syngeneic mice bearing two simultaneously implanted tumors, growth of only one of the tumors was significantly suppressed (61% size reduction at day 15,
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.