Evidence map›Paper›PMID 28729363›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2017

BRG1 (Brahma-Related Gene 1) Promotes Endothelial

Matthew T Menendez, E-Ching Ong, Brian T Shepherd, Vijay Muthukumar, Robert Silasi-Mansat, Florea Lupu, Courtney T Griffin

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. MRTF: Basic Biology and Role in Kidney Disease.International journal of molecular sciences · 2021
    Review
  5. Review
  6. Article
  7. Reporting Sex and Sex Differences in Preclinical Studies.Arteriosclerosis, thrombosis, and vascular biology · 2018
    Article
  8. Vascular Development.Arteriosclerosis, thrombosis, and vascular biology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Matthew T MenendezFrom the Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City (M.T.M., E.-C.O., B.T.S, V.M., R.S.-M., F.L., C.T.G.); and Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City (F.L., C.T.G.).
E-Ching OngFrom the Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City (M.T.M., E.-C.O., B.T.S, V.M., R.S.-M., F.L., C.T.G.); and Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City (F.L., C.T.G.).
Brian T ShepherdFrom the Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City (M.T.M., E.-C.O., B.T.S, V.M., R.S.-M., F.L., C.T.G.); and Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City (F.L., C.T.G.).
Vijay MuthukumarFrom the Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City (M.T.M., E.-C.O., B.T.S, V.M., R.S.-M., F.L., C.T.G.); and Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City (F.L., C.T.G.).
Robert Silasi-MansatFrom the Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City (M.T.M., E.-C.O., B.T.S, V.M., R.S.-M., F.L., C.T.G.); and Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City (F.L., C.T.G.).
Florea LupuFrom the Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City (M.T.M., E.-C.O., B.T.S, V.M., R.S.-M., F.L., C.T.G.); and Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City (F.L., C.T.G.).
Courtney T GriffinFrom the Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City (M.T.M., E.-C.O., B.T.S, V.M., R.S.-M., F.L., C.T.G.); and Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City (F.L., C.T.G.). Courtney-Griffin@omrf.org.
Oklahoma Medical Research Foundation · US

Funding

Pilot ProjectP30GM114731 · NIGMS · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI MCEVER, RODGER PAUL · 2016 to 2020
$6.5M
Regulation of Venous and Lymphatic Identity by Chromatin-RemodelingR01HL111178 · NHLBI · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI GRIFFIN, COURTNEY T · 2012 to 2016
$2.1M
Epigenetic regulation of endothelial cell necroptosis impacts vascular integrityR01HL134778 · NHLBI · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI GRIFFIN, COURTNEY T · 2017 to 2018
$870k
NHLBI NIH HHS R01 HL111178NHLBI NIH HHS R01 HL134778NIGMS NIH HHS P30 GM114731
6 · The paper itself

Abstract

objectiveThe chromatin remodeling enzyme BRG1 (brahma-related gene 1) transcriptionally regulates target genes important for early blood vessel development and primitive hematopoiesis. However, because APPROACH AND

resultsUsing mice with temporally inducible deletion of endothelial BRG1 (

conclusionsBRG1 promotes transcription of endothelial

Indexed as

Gene Expression Regulation, DevelopmentalNeovascularization, PhysiologicTranscription, GeneticAnimalsAntigens, CDBinding SitesCadherin 5CadherinsCapillariesCell LineDNA HelicasesEndothelial CellsEpigenesis, GeneticGenotypeGestational AgeIntegrasesAntigens, CDCadherin 5CadherinsCre recombinaseDNA HelicasesIntegrasesMrtfa protein, mousemyocardin-related transcription factor B, mouseNuclear ProteinsSerum Response FactorSmarca4 protein, mouseTrans-ActivatorsTranscription FactorsBRG1MRTF-AMRTF-Bserum response factorSWI/SNF

Identifiers

PMID28729363
PMCPMC5570645
OpenAlexW2737178771

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.