Evidence map›Paper›PMID 28729298›Full record

ArticleThorax2017

Rapid decline in lung function is temporally associated with greater metabolically active adiposity in a longitudinal study of healthy adults.

Maan Moualla, Clifford Qualls, Alexander Arynchyn, Bharat Thyagarajan, Ravi Kalhan, Lewis J Smith, John J Carr, David R Jacobs, Akshay Sood

Open access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Thorax, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Body Composition and COPD: A New Perspective.International journal of chronic obstructive pulmonary disease · 2023
    Review
  4. Observational
  5. Lung function and cardiovascular disease: A link.Trends in cardiovascular medicine · 2021
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Maan MouallaDepartment of Medicine, School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
Clifford QuallsOffice of Research, Clinical Translational Science Center, University of New Mexico, Albuquerque, New Mexico, USA.
Alexander ArynchynDivision of Preventive Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Bharat ThyagarajanUniversity of Minnesota, Department of Laboratory Medicine and Pathology, Minneapolis, Minnesota, USA.
Ravi KalhanDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Lewis J SmithDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
John J CarrDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
David R JacobsDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.
Akshay SoodDepartment of Medicine, School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
University of New Mexico · USNorthwestern University · USUniversity of Minnesota · USUniversity of Alabama at Birmingham · USVanderbilt University Medical Center · US

Funding

University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
Transitions from Impaired Respiratory Health to Lung DiseaseR01HL122477 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI RAVI KALHAN · 2014 to 2026
$17.3M
NHLBI NIH HHS R01 HL122477NIDDK NIH HHS P30 DK079626
6 · The paper itself

Abstract

rationaleAdiposity is associated with low lung function, but the longitudinal relationship between lung function and adiposity is inadequately studied.

objectiveTo examine the bidirectional longitudinal associations between rapid decline in lung function and adiposity phenotypes in healthy adults.

methodsThis secondary analysis used a 25-year longitudinal dataset from the Coronary Artery Risk Development in Young Adults (CARDIA) study that enrolled 5115 participants. MEASUREMENTS: In the first analysis, metabolic syndrome at or before CARDIA year (Y) 10 (Y10) was the predictor, and subsequent rapid decline in forced vital capacity (FVC) or forced expiratory volume in 1 s (FEV

resultsMetabolic syndrome at or before Y10 is temporally associated with rapid decline in FVC between Y10 and Y20 (adjusted p=0.04), but this association was explained by body mass index (BMI) at Y10. Rapid decline in FVC or FEV

conclusionsHealthy adults with rapid decline in lung function are at risk for developing metabolic syndrome and for disproportionate accumulation of intrathoracic visceral fat. Metabolic abnormalities may be an early extrapulmonary manifestation of lung impairment that may be preventable by improving lung health.

Indexed as

AdiposityAdultAnthropometryBody Mass IndexDisease ProgressionFemaleForced Expiratory VolumeHumansIntra-Abdominal FatLongitudinal StudiesMaleMetabolic SyndromeMiddle AgedSocial ClassVital CapacityBody mass indexmetabolic syndromevisceral fat

Identifiers

PMID28729298
PMCPMC6158777
OpenAlexW2739188813

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.