Evidence map›Paper›PMID 28729292›Full record

ArticleAJNR. American journal of neuroradiology2017

Amide Proton Transfer Imaging Allows Detection of Glioma Grades and Tumor Proliferation: Comparison with Ki-67 Expression and Proton MR Spectroscopy Imaging.

C Su, C Liu, L Zhao, J Jiang, J Zhang, S Li, W Zhu, J Wang

Open access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 4 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 4 syntheses or guidelines pooled it, 66 citations in OpenAlex.

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  16. Biogenic Imaging Contrast Agents.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

C SuFrom the Department of Radiology (C.S., C.L., L.Z., J.J., J.Z., S.L., W.Z.), Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Hankou, Wuhan, People's Republic of China.ORCID http://orcid.org/0000-0002-4418-5823
C LiuFrom the Department of Radiology (C.S., C.L., L.Z., J.J., J.Z., S.L., W.Z.), Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Hankou, Wuhan, People's Republic of China.ORCID http://orcid.org/0000-0002-5579-9230
L ZhaoFrom the Department of Radiology (C.S., C.L., L.Z., J.J., J.Z., S.L., W.Z.), Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Hankou, Wuhan, People's Republic of China.ORCID http://orcid.org/0000-0002-2551-2999
J JiangFrom the Department of Radiology (C.S., C.L., L.Z., J.J., J.Z., S.L., W.Z.), Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Hankou, Wuhan, People's Republic of China.ORCID http://orcid.org/0000-0002-0852-930X
J ZhangFrom the Department of Radiology (C.S., C.L., L.Z., J.J., J.Z., S.L., W.Z.), Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Hankou, Wuhan, People's Republic of China.ORCID http://orcid.org/0000-0002-9415-4953
S LiFrom the Department of Radiology (C.S., C.L., L.Z., J.J., J.Z., S.L., W.Z.), Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Hankou, Wuhan, People's Republic of China.ORCID http://orcid.org/0000-0002-7547-9066
W ZhuFrom the Department of Radiology (C.S., C.L., L.Z., J.J., J.Z., S.L., W.Z.), Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Hankou, Wuhan, People's Republic of China zhuwenzhen8612@163.com.ORCID http://orcid.org/0000-0002-0254-6563
J WangDepartment of Radiation Physics (J.W.), The University of Texas MD Anderson Cancer Center, Houston, Texas.ORCID http://orcid.org/0000-0003-0073-7443
Tongji Hospital · CNThe University of Texas MD Anderson Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposePrognosis in glioma depends strongly on tumor grade and proliferation. In this prospective study of patients with untreated primary cerebral gliomas, we investigated whether amide proton transfer-weighted imaging could reveal tumor proliferation and reliably distinguish low-grade from high-grade gliomas compared with Ki-67 expression and proton MR spectroscopy imaging. MATERIALS AND

methodsThis study included 42 patients with low-grade (

resultsThe asymmetric magnetization transfer ratio at 3.5 ppm values measured by different readers showed good concordance and were significantly higher in high-grade gliomas than in low-grade gliomas (3.61% ± 0.155 versus 2.64% ± 0.185,

conclusionsThe asymmetric magnetization transfer ratio at 3.5 ppm may serve as a potential biomarker not only for assessing proliferation, but also for predicting histopathologic grades in gliomas.

Indexed as

ProtonsAdultAmidesAspartic AcidBrain NeoplasmsCholineFemaleGliomaHumansImmunohistochemistryKi-67 AntigenMagnetic Resonance SpectroscopyMaleMiddle AgedNeoplasm GradingProspective StudiesAmidesAspartic AcidCholineKi-67 AntigenN-acetylaspartateProtons

Identifiers

PMID28729292
PMCPMC7963688
OpenAlexW2736349975

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.