Evidence map›Paper›PMID 28729247›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2017

Adaptive regulation of pancreatic acinar mitochondrial thiamin pyrophosphate uptake process: possible involvement of epigenetic mechanism(s).

Subrata Sabui, Veedamali S Subramanian, Rubina Kapadia, Hamid M Said

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. miR-122-5p is involved in posttranscriptional regulation of the mitochondrial thiamin pyrophosphate transporter (American journal of physiology. Gastrointestinal and liver physiology · 2023
    Article
  3. Article
  4. Article
  5. Article
  6. Impact of prevailing thiamin levels on thiamin pyrophosphate uptake in pancreatic acinar cells: do the shuttle!American journal of physiology. Gastrointestinal and liver physiology · 2017
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Subrata SabuiDepartment of Medical Research, Veterans Affairs Medical Center, Long Beach, California; and Departments of Medicine and Physiology/Biophysics, University of California, Irvine, California.
Veedamali S SubramanianDepartment of Medical Research, Veterans Affairs Medical Center, Long Beach, California; and Departments of Medicine and Physiology/Biophysics, University of California, Irvine, California.
Rubina KapadiaDepartment of Medical Research, Veterans Affairs Medical Center, Long Beach, California; and Departments of Medicine and Physiology/Biophysics, University of California, Irvine, California.
Hamid M SaidDepartment of Medical Research, Veterans Affairs Medical Center, Long Beach, California; and Departments of Medicine and Physiology/Biophysics, University of California, Irvine, California hmsaid@uci.edu.
University of California, Irvine · US

Funding

INTESTINAL VITAMIN H UPTAKE--MOLECULAR/CELL REGULATIONR01DK058057 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI SAID, HAMID M · 2000 to 2019
$6.8M
Physiology/Pathophysiology of Vitamin B1 Transport in Pancreatic Acinar CellsR01AA018071 · NIAAA · UNIVERSITY OF CALIFORNIA-IRVINE · PI SAID, HAMID M · 2009 to 2023
$6.3M
Vitamin B1 (thiamin) transport in Alzheimer’s Disease: Role of microRNAs in regulating level of expression of its transporters (SLC19A2 & SLC19A3) in human brain cells and effect of hypoxiaR01DK056061 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI SAID, HAMID M · 1999 to 2024
$5.0M
Mechanism/Regulation of Intestinal Thiamin UptakeR37DK056061 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI SAID, HAMID M · 2009 to 2018
$3.6M
Physiology/pathophysiology of intestinal vitC uptake: Cell/molecular mechanismsR01DK107474 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI SUBRAMANIAN, VEEDAMALI S · 2016 to 2020
$2.1M
Physiological and Pathological Aspects of Intestinal Vitamin B2 AbsorptionI01BX001142 · VA · VETERANS HEALTH ADMINISTRATION · PI HAMID M SAID · 2011 to 2026
–
BLRD VA I01 BX001142NIAAA NIH HHS R01 AA018071NIDDK NIH HHS R01 DK056061NIDDK NIH HHS R01 DK058057NIDDK NIH HHS R01 DK107474NIDDK NIH HHS R37 DK056061
6 · The paper itself

Abstract

The essentiality of thiamin stems from its roles as a cofactor [mainly in the form of thiamin pyrophosphate (TPP)] in critical metabolic reactions including oxidative energy metabolism and reduction of cellular oxidative stress. Like other mammalian cells, pancreatic acinar cells (PAC) obtain thiamin from their surroundings and convert it to TPP; mitochondria then take up TPP by a carrier-mediated process that involves the mitochondrial TPP (MTPP) transporter (MTPPT; product of

Indexed as

Anion Transport ProteinsMembrane Transport ProteinsMitochondrial ProteinsPancreas, ExocrineThiamineAcinar CellsAdaptation, BiologicalAnimalsBiological Transport, ActiveEnergy MetabolismHumansMiceMitochondriaMitochondrial Membrane Transport ProteinsOxidative StressThiamine DeficiencyAnion Transport ProteinsMembrane Transport ProteinsMitochondrial Membrane Transport ProteinsMitochondrial ProteinsSLC25A19 protein, humanSlc25a19 protein, mouseThiamineThiamine Pyrophosphatemitochondrial uptakepancreatic acinar cellsSLC25A19thiamin pyrophosphatetranscriptional regulation

Identifiers

PMID28729247
PMCPMC5792211
OpenAlexW2739011479

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.