ArticleArchives of physical medicine and rehabilitation2017
Pain, Fatigue, and Cognitive Symptoms Are Temporally Associated Within but Not Across Days in Multiple Sclerosis.
Article in Archives of physical medicine and rehabilitation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Brain connectivity changes underlying depression and fatigue in relapsing-remitting multiple sclerosis: A systematic review.PloS one · 2024Pooled it
- Determining minimal clinically important differences in ecological momentary assessment measures of fatigue in people with multiple sclerosis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Trial
- Examining the Impact of Perceived and Objective Cognitive Function on Social Participation in Individuals With Multiple Sclerosis.Archives of physical medicine and rehabilitation · 2026Article
- Promoting Exercise as a Therapeutic Intervention in Multiple Sclerosis: Barriers, Efficacy, and Social Prescribing Strategies.Cardiology and cardiovascular medicine · 2026Article
- Article
- A Mindfulness-Based Lifestyle Intervention for Dementia Risk Reduction: Protocol for the My Healthy Brain Feasibility Randomized Controlled Trial.JMIR research protocols · 2024Article
- Optimizing Detection and Prediction of Cognitive Function in Multiple Sclerosis With Ambulatory Cognitive Tests: Protocol for the Longitudinal Observational CogDetect-MS Study.JMIR research protocols · 2024Article
- Daily patterns of fatigue after subarachnoid haemorrhage: an ecological momentary assessment study.Journal of rehabilitation medicine · 2023Observational
- Dietary Patterns and Their Associations with Symptom Levels Among People with Multiple Sclerosis: A Real-World Digital Study.Neurology and therapy · 2023Article
- Coping as a Moderator of Associations Between Symptoms and Functional and Affective Outcomes in the Daily Lives of Individuals With Multiple Sclerosis.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2023Article
- Dynamics of Loneliness Among Older Adults During the COVID-19 Pandemic: Pilot Study of Ecological Momentary Assessment With Network Analysis.Frontiers in digital health · 2022Article
- The role of pain and psychological distress in fatigue: a co-twin and within-person analysis of confounding and causal relations.Health psychology and behavioral medicine · 2022Article
- Real-time associations among MS symptoms and cognitive dysfunction using ecological momentary assessment.Frontiers in medicine · 2022Article
- How to measure fluctuating impairments in people with MS: development of an ambulatory assessment version of the EQ-5D-5L in an exploratory study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021Article
- An observational cohort study on impact, dimensions and outcome of perceived fatigue in adult 5q-spinal muscular atrophy patients receiving nusinersen treatment.Journal of neurology · 2021Observational
- Daily Temporal Associations Between Physical Activity and Symptoms in Multiple Sclerosis.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2019Article
- Phenotypic Features of Central Sensitization.Journal of applied biobehavioral research · 2018Article
- Psychiatric and physical comorbidities and pain in patients with multiple sclerosis.Journal of pain research · 2018Article
- Potentials and barriers of using digital tools for collecting daily measurements in multiple sclerosis research.Digital healthArticle
- Characterizing Relationships Between Cognitive, Mental, and Physical Health and Physical Activity Levels in Persons With Multiple Sclerosis.International journal of MS careArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo examine the temporal associations, within day and day to day, between pain, fatigue, depressed mood, and cognitive function in multiple sclerosis (MS).
designRepeated-measures study involving 7 days of ecological momentary assessment (EMA) of symptoms 5 times a day; multilevel mixed models were used to analyze data.
settingCommunity.
participantsAmbulatory adults (N=107) with MS.
interventionsNot applicable.
main outcome measureEMA of pain, fatigue, depressed mood, and cognitive function rated on a 0 to 10 scale.
resultsFatigue and pain were linked within day such that higher pain was associated with higher subsequent fatigue (B=.09, P=.04); likewise, higher fatigue was associated with higher pain in the following time frame (B=.05, P=.04). Poorer perceived cognitive function preceded increased subsequent pain (B=.08, P=.007) and fatigue (B=.10, P=.01) within day. Depressed mood was not temporally linked with other symptoms. In terms of day-to-day effects, a day of higher fatigue related to decreased next day fatigue (B=-.16, P=.01), and a day of higher depressed mood related to increased depressed mood the next day (B=.17, P=.01). There were no cross-symptom associations from one day to the next.
conclusionsFindings provide new insights on how common symptoms in MS relate to each other and vary within and over days. Pain and fatigue show evidence of a dynamic bidirectional relation over the course of a day, and worsening of perceived cognitive function preceded worsening of both pain and fatigue. Most temporal associations between symptoms occur within the course of a day, with relatively little carryover from one day to the next.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.