ReviewBiochimica et biophysica acta. Molecular basis of disease2018
Non-human primates as a model for aging.
Review in Biochimica et biophysica acta. Molecular basis of disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
98 citing papers in PubMed, 1 synthesis or guideline pooled it, 153 citations in OpenAlex.
- Severe acute respiratory syndrome coronavirus-2 natural animal reservoirs and experimental models: systematic review.Reviews in medical virology · 2021Pooled it
- Species-dependent activities of the PINK1-parkin axis.Translational neurodegeneration · 2026Review
- Modeling Tau-Mediated Pathology in Monkey Brain Slices.Biology · 2026Article
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- Immune gene expression dynamics across the lifespan of Tibetan macaques (Current zoology · 2026Article
- Age-associated hematopoietic variants in the rhesus macaque.Blood advances · 2026Article
- Evaluating Subtypes of Endometriosis in Rhesus Macaques (Macaca mulatta) Using Clinical Findings and Immunohistochemistry.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- Hand Musculature of the Common Marmoset (Veterinary sciences · 2026Article
- Marmoset (Callithrix jacchus) Swallowing Physiology: Novel Dysphagia Model Across Lifespan.Integrative and comparative biology · 2026Article
- Article
- A multi-omics molecular landscape of 30 tissues in aging female rhesus macaques.Nature methods · 2025Article
- Review
- Age-Related Changes in Marmoset (Callithrix jacchus) Feeding Behavior and Physiology: Insights of Masticatory and Swallowing Functions.American journal of primatology · 2025Article
- Studying ovarian aging and its health impacts: modern tools and approaches.Genes & development · 2025Review
- Article
- Stem cell-derived small extracellular vesicles containing miR-27b-3p attenuated osteoarthritis through inhibition of leukaemia inhibitory factor.Fundamental research · 2025Article
- Cellular immunophenotyping in human and primate tissues during healthy conditions and Ebola and Nipah infections.JCI insight · 2025Article
- The Evolution of Experimental Rodent Models for Prion Diseases.Journal of neurochemistry · 2025Review
38 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
There has been, and continues to be, a dramatic shift in the human population towards older ages necessitating biomedical research aimed at better understanding the basic biology of aging and age-related diseases and facilitating new and improved therapeutic options. As it is not practical to perform the breadth of this research in humans, animal models are necessary to recapitulate the complexity of the aging environment. The mouse model is most frequently chosen for these endeavors, however, they are frequently not the most appropriate model. Non-human primates, on the other hand, are more closely related to humans and recapitulate the human aging process and development of age-related diseases. Extensive aging research has been performed in the well-characterized rhesus macaque aging model. More recently, the common marmoset, a small non-human primate with a shorter lifespan, has been explored as a potential aging model. This model holds particular promise as an aging disease model in part due to the successful creation of transgenic marmosets. Limitations to the use of non-human primates in aging research exist but can be mitigated somewhat by the existence of available resources supported by the National Institutes of Health. This article is part of a Special Issue entitled: Animal models of aging - edited by "Houtkooper Riekelt".
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.