ArticleJournal of theoretical biology2017
Conditions for success of engineered underdominance gene drive systems.
Article in Journal of theoretical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Seed dormancy shapes gene drive dynamics in plants.Nature plants · 2026Article
- Ecology of Gene Drives: The Role of Density-Dependent Feedbacks on the Efficacy and Dynamics of Two-Locus Underdominance Gene Drive Systems.Evolutionary applications · 2025Article
- Harnessing Wolbachia cytoplasmic incompatibility alleles for confined gene drive: A modeling study.PLoS genetics · 2023Article
- Modeling-informed Engineered Genetic Incompatibility strategies to overcome resistance in the invasiveFrontiers in insect science · 2022Article
- Design and analysis of CRISPR-based underdominance toxin-antidote gene drives.Evolutionary applications · 2021Article
- Novel combination of CRISPR-based gene drives eliminates resistance and localises spread.Scientific reports · 2021Article
- Control of malaria-transmitting mosquitoes using gene drives.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Split drive killer-rescue provides a novel threshold-dependent gene drive.Scientific reports · 2020Article
- Adequacy and sufficiency evaluation of existing EFSA guidelines for the molecular characterisation, environmental risk assessment and post-market environmental monitoring of genetically modified insects containing engineered gene drives.EFSA journal. European Food Safety Authority · 2020Article
- Population Dynamics of Underdominance Gene Drive Systems in Continuous Space.ACS synthetic biology · 2020Article
- Mathematical modeling of self-contained CRISPR gene drive reversal systems.Scientific reports · 2019Article
- Modeling the mutation and reversal of engineered underdominance gene drives.Journal of theoretical biology · 2019Article
- Tethered homing gene drives: A new design for spatially restricted population replacement and suppression.Evolutionary applications · 2019Article
- Recent advances in threshold-dependent gene drives for mosquitoes.Biochemical Society transactions · 2018Review
- Invasion and migration of spatially self-limiting gene drives: A comparative analysis.Evolutionary applications · 2018Article
- Considerations for the governance of gene drive organisms.Pathogens and global health · 2018Review
- Population dynamics of engineered underdominance and killer-rescue gene drives in the control of disease vectors.PLoS computational biology · 2018Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Engineered underdominance is one of a number of different gene drive strategies that have been proposed for the genetic control of insect vectors of disease. Here we model a two-locus engineered underdominance based gene drive system that is based on the concept of mutually suppressing lethals. In such a system two genetic constructs are introduced, each possessing a lethal element and a suppressor of the lethal at the other locus. Specifically, we formulate and analyse a population genetics model of this system to assess when different combinations of release strategies (i.e. single or multiple releases of both sexes or males only) and genetic systems (i.e. bisex lethal or female-specific lethal elements and different strengths of suppressors) will give population replacement or fail to do so. We anticipate that results presented here will inform the future design of engineered underdominance gene drive systems as well as providing a point of reference regarding release strategies for those looking to test such a system. Our discussion is framed in the context of genetic control of insect vectors of disease. One of several serious threats in this context are Aedes aegypti mosquitoes as they are the primary vectors of dengue viruses. However, results are also applicable to Ae. aegypti as vectors of Zika, yellow fever and chikungunya viruses and also to the control of a number of other insect species and thereby of insect-vectored pathogens.
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Registered trials
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