Evidence map›Paper›PMID 28728817›Full record

ReviewCurrent topics in membranes2017

Piezo2 in Cutaneous and Proprioceptive Mechanotransduction in Vertebrates.

E O Anderson, E R Schneider, S N Bagriantsev

Open access · greenAbstract readReview
In one paragraph

Review in Current topics in membranes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
12.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Lipid Regulation of Mechanosensitive Ion Channels.International journal of molecular sciences · 2026
    Review
  3. The Role of Myofibroblasts in Physiological and Pathological Tissue Repair.Cold Spring Harbor perspectives in biology · 2023
    Review
  4. Merkel Cell Carcinoma Display PIEZO2 Immunoreactivity.Journal of personalized medicine · 2022
    Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Sensory Innervation of the Larynx and the Search for Mucosal Mechanoreceptors.Journal of speech, language, and hearing research : JSLHR · 2021
    Article
  11. Review
  12. The Emerging Role of Mechanosensitive Piezo Channels in Migraine Pain.International journal of molecular sciences · 2020
    Review
  13. Piezo2 integrates mechanical and thermal cues in vertebrate mechanoreceptors.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

E O AndersonYale University, New Haven, CT, United States.
E R SchneiderYale University, New Haven, CT, United States.
S N BagriantsevYale University, New Haven, CT, United States.
Yale University · US

Funding

Role of Piezo2 and Nav channels in rapidly-adapting neuronal mechanoreceptorsR01NS097547 · NINDS · YALE UNIVERSITY · PI Sviatoslav Bagriantsev · 2017 to 2026
$4.1M
RESEARCH IN PERINATAL MEDICINET32HD007094 · NICHD · YALE UNIVERSITY · PI GALLAGHER, PATRICK G · 1985 to 2015
$3.6M
Training Program in Molecular MedicineT32GM100884 · NIGMS · YALE UNIVERSITY · PI LISTER, GEORGE, NITABACH, MICHAEL · 2013 to 2022
$1.8M
NICHD NIH HHS T32 HD007094NIGMS NIH HHS T32 GM100884NINDS NIH HHS R01 NS097547
6 · The paper itself

Abstract

Mechanosensitivity is a fundamental physiological capacity, which pertains to all life forms. Progress has been made with regard to understanding mechanosensitivity in bacteria, flies, and worms. In vertebrates, however, the molecular identity of mechanotransducers in somatic and neuronal cells has only started to appear. The Piezo family of mechanogated ion channels marks a pivotal milestone in understanding mechanosensitivity. Piezo1 and Piezo2 have now been shown to participate in a number of processes, ranging from arterial modeling to sensing muscle stretch. In this review, we focus on Piezo2 and its role in mediating mechanosensation and proprioception in vertebrates.

Indexed as

Mechanotransduction, CellularProprioceptionSkin Physiological PhenomenaAnimalsHumansIon ChannelsMerkel CellsVertebratesIon ChannelsDorsal root gangliaMechanoreceptionMechanosensitivityMechanotransductionPiezo2ProprioceptionSomatosensitivityTrigeminal ganglia

Identifiers

PMID28728817
PMCPMC5630267
OpenAlexW2595630222

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.