ArticleBiological psychiatry2018
Increased Striatal Dopamine Synthesis Capacity in Gambling Addiction.
Article in Biological psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 113 citations in OpenAlex.
- Shared gray matter alterations in individuals with diverse behavioral addictions: A voxel-wise meta-analysis.Journal of behavioral addictions · 2020Pooled it
- Non-invasive Brain Stimulation for Gambling Disorder: A Systematic Review.Frontiers in neuroscience · 2020Pooled it
- Trial
- Motivation, attention, and uncertainty: insights from animal and human research and implications for addiction.Frontiers in psychology · 2026Review
- Tonic dopamine and biases in value learning linked through a biologically inspired reinforcement learning model.Nature communications · 2025Article
- The neural vulnerabilities in reward processing in gambling disorder.Journal of behavioral addictions · 2025Article
- Similarities and Differences in Neurobiology.Advances in experimental medicine and biology · 2025Review
- Article
- Decomposition of Reinforcement Learning Deficits in Disordered Gambling via Drift Diffusion Modeling and Functional Magnetic Resonance Imaging.Computational psychiatry (Cambridge, Mass.) · 2024Article
- Neurotransmitters crosstalk and regulation in the reward circuit of subjects with behavioral addiction.Frontiers in psychiatry · 2024Review
- Dopamine regulates decision thresholds in human reinforcement learning in males.Nature communications · 2023Article
- Article
- Neuroimaging of Dopamine Transporter Density in the Striatum of Disordered Gamblers.Journal of gambling studies · 2023Article
- Individuals with problem gambling and obsessive-compulsive disorder learn through distinct reinforcement mechanisms.PLoS biology · 2023Article
- Serotonergic and dopaminergic control of impulsivity in gambling disorder.Addiction biology · 2023Article
- Caudate gray matter volumes and risk of relapse in Type A alcohol-dependent patients: A 7-year MRI follow-up study.Frontiers in psychiatry · 2023Article
- Effects of average reward rate on vigor as a function of individual variation in striatal dopamine.Psychopharmacology · 2022Article
- Article
- Attenuated Directed Exploration during Reinforcement Learning in Gambling Disorder.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Risky decision-making following prefrontal D1 receptor manipulation.Translational neuroscience · 2021Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundThe hypothesis that dopamine plays an important role in the pathophysiology of pathological gambling is pervasive. However, there is little to no direct evidence for a categorical difference between pathological gamblers and healthy control subjects in terms of dopamine transmission in a drug-free state. Here we provide evidence for this hypothesis by comparing dopamine synthesis capacity in the dorsal and ventral parts of the striatum in 13 pathological gamblers and 15 healthy control subjects.
methodsThis was achieved using [
resultsOur results show that dopamine synthesis capacity was increased in pathological gamblers compared with healthy control subjects. Dopamine synthesis was 16% higher in the caudate body, 17% higher in the dorsal putamen, and 17% higher in the ventral striatum in pathological gamblers compared with control subjects. Moreover, dopamine synthesis capacity in the dorsal putamen and caudate head was positively correlated with gambling distortions in pathological gamblers.
conclusionsTaken together, these results provide empirical evidence for increased striatal dopamine synthesis in pathological gambling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.