ArticleBMC research notes2017
Antimicrobial susceptibility pattern of clinical isolates of Burkholderia pseudomallei in Bangladesh.
Article in BMC research notes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 32 citations in OpenAlex.
- Article
- Melioidosis molecular diagnostics: An update.Virulence · 2025Review
- Postexposure Antimicrobial Drug Therapy in Goats Infected with Burkholderia pseudomallei.Emerging infectious diseases · 2025Article
- Article
- Expression of virulence and antimicrobial related proteins in Burkholderia mallei and Burkholderia pseudomallei.PLoS neglected tropical diseases · 2023Article
- Showing the limitations of available phenotypic assays to detectAccess microbiology · 2023Article
- Effective Therapeutic Options for Melioidosis: Antibiotics versus Phage Therapy.Pathogens (Basel, Switzerland) · 2022Review
- A mathematical model analysis of the human melioidosis transmission dynamics with an asymptomatic case.Heliyon · 2022Article
- Oral Melioidosis in Odontogenic Keratocyst of Mandible.Journal of maxillofacial and oral surgery · 2022Article
- The Epidemiology of Melioidosis and Its Association with Diabetes Mellitus: A Systematic Review and Meta-Analysis.Pathogens (Basel, Switzerland) · 2022Article
- Antimicrobial Susceptibility of Western Hemisphere Isolates ofMicrobial drug resistance (Larchmont, N.Y.) · 2021Article
- Drug screening to identify compounds to act as co-therapies for the treatment of Burkholderia species.PloS one · 2021Article
- Multi locus sequence typing of clinical Burkholderia pseudomallei isolates from Malaysia.PLoS neglected tropical diseases · 2020Article
- Safer In Vitro Drug Screening Models for Melioidosis Therapy Development.The American journal of tropical medicine and hygiene · 2020Article
- Human Melioidosis.Clinical microbiology reviews · 2020Review
- Pan-drug-resistant and biofilm-producing strain ofInternational medical case reports journal · 2019Article
- The first imported case of melioidosis in a patient in central China.Emerging microbes & infections · 2019Article
- Melioidosis in Bangladesh: A Clinical and Epidemiological Analysis of Culture-Confirmed Cases.Tropical medicine and infectious disease · 2018Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMelioidosis an infectious disease, caused by a Gram negative bacterium called Burkholderia pseudomallei, is endemic in Bangladesh. This organism is sensitive to limited number of antimicrobial agents and need prolonged treatment. There is no comprehensive data on the antimicrobial susceptibility profile of B. pseudomallei isolated in Bangladesh over last several years. The present study aimed to determine the antimicrobial susceptibility pattern of B. pseudomallei isolated in a tertiary care hospital of Dhaka city from 2009 to 2015.
methodsAll B. pseudomallei isolated from melioidosis patients over a period of 7 years (2009-2015) in the Department of Microbiology of a 725-bed tertiary care referral hospital in Dhaka city, Bangladesh were included in the study. B. pseudomallei was identified by Gram stain, culture, specific biochemical tests, serology and PCR using specific primers constructed from 16s rRNA region of B. pseudomallei. Antimicrobial susceptibility to specific agents was determined by disk diffusion and minimum inhibitory concentration methods.
resultsA total of 20 isolates of B. pseudomallei which were isolated from patients coming from different geographic locations of Bangladesh were included in the study. All the isolates were uniformly sensitive (100%) to ceftazidime, imipenem, piperacillin-tazobactam, amoxicillin-clavulanic acid and tetracycline by both disk diffusion and MIC methods. Two strains were resistant to trimethoprim-sulfamethoxazole by disk diffusion method but were sensitive by MIC method. The MIC
conclusionThe results of the study suggest that B. pseudomallei prevalent in Bangladesh were still susceptible to all recommended antimicrobial agents used for the treatment of melioidosis. However, regular monitoring is needed to detect any emergence of resistance and shifting of MIC
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