Evidence map›Paper›PMID 28727979›Full record

ArticlePulmonary circulation

Hypercapnic acidosis attenuates pressure-dependent increase in whole-lung filtration coefficient (K

Nikhil Bommakanti, Ayman Isbatan, Avni Bavishi, Gourisree Dharmavaram, Andreia Z Chignalia, Randal O Dull

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pulmonary circulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. The Glycocalyx and Pressure-Dependent Transcellular Albumin Transport.Cardiovascular engineering and technology · 2020
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Nikhil Bommakanti1 Department of Anesthesiology, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA.
Ayman Isbatan1 Department of Anesthesiology, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA.
Avni Bavishi1 Department of Anesthesiology, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA.
Gourisree Dharmavaram1 Department of Anesthesiology, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA.
Andreia Z Chignalia1 Department of Anesthesiology, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA.
Randal O Dull1 Department of Anesthesiology, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA.
Illinois College · USUniversity of Illinois Chicago · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypercapnic acidosis (HCA) has beneficial effects in experimental models of lung injury by attenuating inflammation and decreasing pulmonary edema. However, HCA increases pulmonary vascular pressure that will increase fluid filtration and worsen edema development. To reconcile these disparate effects, we tested the hypothesis that HCA inhibits endothelial mechanotransduction and protects against pressure-dependent increases in the whole lung filtration coefficient (K

Indexed as

filtration coefficienthypercapnic acidosismechanotransductionpulmonary edemarat

Identifiers

PMID28727979
PMCPMC5841912
OpenAlexW2738438208

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.