Evidence map›Paper›PMID 28727771›Full record

Trial reportPloS one2017

Randomized controlled trial on the effects of a supervised high intensity exercise program in patients with a hematologic malignancy treated with autologous stem cell transplantation: Results from the EXIST study.

Saskia Persoon, Mai J M ChinAPaw, Laurien M Buffart, Roberto D K Liu, Pierre Wijermans, Harry R Koene, Monique C Minnema, Pieternella J Lugtenburg, Erik W A Marijt, Johannes Brug and 2 more

Open access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 15 pooled it
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 15 syntheses or guidelines pooled it, 100 citations in OpenAlex.

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  4. Management of Fatigue in Adult Survivors of Cancer: ASCO-Society for Integrative Oncology Guideline Update.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
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  12. Exercise on quality of life and cancer-related fatigue for lymphoma survivors: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
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  15. Efficacy of Exercise Therapy on Cardiorespiratory Fitness in Patients With Cancer: A Systematic Review and Meta-Analysis.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 1 country.

Saskia PersoonDepartment of Rehabilitation, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Mai J M ChinAPawVU University Medical Center, Department of Public and Occupational Health and the EMGO+ Institute for Health and Care Research, Amsterdam, The Netherlands.
Laurien M BuffartVU University Medical Center, Department of Epidemiology and Biostatistics and the EMGO+ Institute for Health and Care Research, Amsterdam, The Netherlands.
Roberto D K LiuDepartment of Hematology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Pierre WijermansDepartment of Hematology, Haga Teaching Hospital, The Hague, The Netherlands.
Harry R KoeneDepartment of Internal Medicine, St. Antonius Hospital, Nieuwegein, The Netherlands.
Monique C MinnemaDepartment of Hematology, UMC Utrecht, Utrecht, The Netherlands.
Pieternella J LugtenburgDepartment of Hematology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Erik W A MarijtDepartment of Hematology, Leiden University Medical Center, Leiden, The Netherlands.
Johannes BrugVU University Medical Center, Department of Epidemiology and Biostatistics and the EMGO+ Institute for Health and Care Research, Amsterdam, The Netherlands.
Frans NolletDepartment of Rehabilitation, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Marie José KerstenDepartment of Hematology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Academic Medical Center · NLEMGO Institute for Health and Care Research · NLErasmus MC Cancer Institute · NLHaga Hospital · NLLeiden University Medical Center · NLSt. Antonius Ziekenhuis · NLUniversity of Amsterdam · NLUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis single blind, multicenter randomized controlled trial aimed to evaluate the effectiveness of a supervised high intensity exercise program on physical fitness and fatigue in patients with multiple myeloma or lymphoma recently treated with autologous stem cell transplantation.

methods109 patients were randomly assigned to the 18-week exercise intervention or the usual care control group. The primary outcomes included physical fitness (VO2peak and Wpeak determined using a cardiopulmonary exercise test; grip strength and the 30s chair stand test) and fatigue (Multidimensional Fatigue Inventory) and were assessed prior to randomization and after completion of the intervention or at similar time points for the control group. Multivariable multilevel linear regression analyses were performed to assess intervention effects.

resultsPatients in the intervention group attended 86% of the prescribed exercise sessions. Of the patients in the control group, 47% reported ≥10 physiotherapy sessions, which most likely included supervised exercise, suggesting a high rate of contamination. Median improvements in physical fitness ranged between 16 and 25% in the intervention group and between 12 and 19% in the control group. Fatigue decreased in both groups. There were no significant differences between the intervention and control group.

conclusionWe found no significant beneficial effects of the supervised high intensity exercise program on physical fitness and fatigue when compared to usual care. We hypothesized that the lack of significant intervention effects may relate to suboptimal timing of intervention delivery, contamination in the control group and/or suboptimal compliance to the prescribed exercise intervention.

trial registrationNetherlands Trial Register-NTR2341.

Indexed as

Exercise TherapyHigh-Intensity Interval TrainingPhysical FitnessAdultAgedDrug-Related Side Effects and Adverse ReactionsFemaleHumansLymphomaMaleMiddle AgedMultiple MyelomaSingle-Blind Method

Identifiers

PMID28727771
PMCPMC5519072
OpenAlexW2737584748

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.