ArticlePloS one2017
Detection of titin fragments in urine in response to exercise-induced muscle damage.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Fluid balance and hydration status in combat sport Olympic athletes: a systematic review with meta-analysis of controlled and uncontrolled studies.European journal of nutrition · 2019Pooled it
- Beverage-Specific Modulation of Urinary Inflammatory Biomarkers After Endurance Running in Trained Males.Nutrients · 2025Trial
- Systemic proteomic dynamics of acute exercise reveal genetic links to health and disease.Nature metabolism · 2026Article
- Urinary N-terminal titin fragment concentration as a non-invasive biomarker of exercise-induced muscle damage in males and females.European journal of applied physiology · 2026Article
- Urinary titin represents an exciting biomarker for assessment of muscle health.Journal of muscle research and cell motility · 2025Review
- The Diagnostic Potential of Urinary Titin Fragment in Neuromuscular Diseases.International journal of molecular sciences · 2025Review
- Universal Proteomic Signature After Exercise-Induced Muscle Injury in Muscular Dystrophies.Annals of clinical and translational neurology · 2025Article
- Urinary titin as a biomarker of sarcopenia in diabetes: a propensity score matching analysis.Journal of endocrinological investigation · 2025Article
- Circulatory titin and miR-451a are possible sarcopenia biomarkers in elderly people.Frontiers in aging · 2025Article
- The Utility of Urinary Titin to Diagnose and Predict the Prognosis of Acute Myocardial Infarction.International journal of molecular sciences · 2024Article
- Relationships between Changes in Muscle Shear Modulus, Urinary Titin N- Terminal Fragment, and Maximum Voluntary Contraction Torque after Eccentric Exercise of the Elbow Flexors.Journal of sports science & medicine · 2023Article
- Calpain-3 Is Not a Sodium Dependent Protease and Simply Requires Calcium for Activation.International journal of molecular sciences · 2023Article
- Pre-sleep protein supplementation does not improve recovery from load carriage in British Army recruits (part 2).Frontiers in nutrition · 2023Article
- Urinary titin is not an early biomarker of skeletal muscle atrophy induced by muscle denervation in mice.PloS one · 2023Article
- Changes in Muscle Shear Modulus and Urinary Titin N-Terminal Fragment after Eccentric Exercise.Journal of sports science & medicine · 2022Article
- Redox-related biomarkers in physical exercise.Redox biology · 2021Review
- An acute eccentric exercise increases circulating myomesin 3 fragments.The journal of physiological sciences : JPS · 2021Article
- Changes in Urinary Biomarkers of Organ Damage, Inflammation, Oxidative Stress, and Bone Turnover Following a 3000-m Time Trial.Antioxidants (Basel, Switzerland) · 2021Article
- Towards Personalized Management of Sarcopenia in COPD.International journal of chronic obstructive pulmonary disease · 2021Review
- Pathophysiology of exercise-induced muscle damage and its structural, functional, metabolic, and clinical consequences.Physiological research · 2020Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many studies have attempted to determine the associations between blood biomarkers and exercise-induced muscle damage. However, poor correlations between the changes in biomarker levels and the magnitude of muscle symptoms have been reported. Recent advances in proteomic tools offer a strategy for the comprehensive analysis of protein expression, which can be used to identify biomarkers. Here, we used a proteomic analysis to identify urinary proteins that appear in response to a calf-raise exercise, including repetitive eccentric muscle contractions, and found that a titin (also known as connectin) N-terminal fragment molecule appears in the urine after eccentric exercise. We measured the titin fragment in urine samples from nine individuals before and after eccentric exercise using a newly-established enzyme-linked immunosorbent assay and found that the titin fragment excretion rate increased 96 h after the exercise (5.1 to 77.6 pg/min, p <0.01). The changes in the titin fragment excretion rate were correlated strongly with blood markers of muscle damage and with muscle symptoms. These findings suggest that the urinary titin fragment is potentially a noninvasive biomarker of muscle damage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.