Evidence map›Paper›PMID 28727731›Full record

ArticlePloS one2017

Pregnancy incidence and intention after HIV diagnosis among women living with HIV in Canada.

Kate Salters, Mona Loutfy, Alexandra de Pokomandy, Deborah Money, Neora Pick, Lu Wang, Shahab Jabbari, Allison Carter, Kath Webster, Tracey Conway and 5 more

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.

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  8. HIV infection during pregnancy in the state of Rio de Janeiro, Brazil, 2021-2023.Revista brasileira de epidemiologia = Brazilian journal of epidemiology · 2025
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  16. A practical clinical guide to counselling on and managing contraception, pre-conception planning, and menopause for women living with HIV.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Kate SaltersFaculty of Health Sciences, Simon Fraser University, Burnaby, Canada.ORCID http://orcid.org/0000-0002-6280-2290
Mona LoutfyWomen's College Research Institute, Women's College Hospital, University of Toronto, Toronto, Ontario, Canada.
Alexandra de PokomandyChronic Viral Illness Service, McGill University Health Centre, Montreal, Quebec, Canada.
Deborah MoneyOak Tree Clinic, BC Women's Hospital and Health Centre, Vancouver, Canada.
Neora PickOak Tree Clinic, BC Women's Hospital and Health Centre, Vancouver, Canada.
Lu WangBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Shahab JabbariBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Allison CarterFaculty of Health Sciences, Simon Fraser University, Burnaby, Canada.
Kath WebsterFaculty of Health Sciences, Simon Fraser University, Burnaby, Canada.
Tracey ConwayWomen's College Research Institute, Women's College Hospital, University of Toronto, Toronto, Ontario, Canada.
Daniele DubucChronic Viral Illness Service, McGill University Health Centre, Montreal, Quebec, Canada.
Nadia O'BrienChronic Viral Illness Service, McGill University Health Centre, Montreal, Quebec, Canada.
Karene Proulx-BoucherChronic Viral Illness Service, McGill University Health Centre, Montreal, Quebec, Canada.
Angela KaidaFaculty of Health Sciences, Simon Fraser University, Burnaby, Canada.
CHIWOS Research Team
McGill University Health Centre · CASimon Fraser University · CAAIDS Vancouver · CAUniversity of British Columbia · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPregnancy incidence rates among women living with HIV (WLWH) have increased over time due to longer life expectancy, improved health status, and improved access to and HIV prevention benefits of combination antiretroviral therapy (cART). However, it is unclear whether intended or unintended pregnancies are contributing to observed increases.

methodsWe analyzed retrospective data from the Canadian HIV Women's Sexual and Reproductive Health Cohort Study (CHIWOS). Kaplan-Meier methods and GEE Poisson models were used to measure cumulative incidence and incidence rate of pregnancy after HIV diagnosis overall, and by pregnancy intention. We used multivariable logistic regression models to examine independent correlates of unintended pregnancy among the most recent/current pregnancy.

resultsOf 1,165 WLWH included in this analysis, 278 (23.9%) women reported 492 pregnancies after HIV diagnosis, 60.8% of which were unintended. Unintended pregnancy incidence (24.6 per 1,000 Women-Years (WYs); 95% CI: 21.0, 28.7) was higher than intended pregnancy incidence (16.6 per 1,000 WYs; 95% CI: 13.8, 20.1) (Rate Ratio: 1.5, 95% CI: 1.2-1.8). Pregnancy incidence among WLWH who initiated cART before or during pregnancy (29.1 per 1000 WYs with 95% CI: 25.1, 33.8) was higher than among WLWH not on cART during pregnancy (11.9 per 1000 WYs; 95% CI: 9.5, 14.9) (Rate Ratio: 2.4, 95% CI: 2.0-3.0). Women with current or recent unintended pregnancy (vs. intended pregnancy) had higher adjusted odds of being single (AOR: 1.94; 95% CI: 1.10, 3.42), younger at time of conception (AOR: 0.95 per year increase, 95% CI: 0.90, 0.99), and being born in Canada (AOR: 2.76, 95% CI: 1.55, 4.92).

conclusionNearly one-quarter of women reported pregnancy after HIV diagnosis, with 61% of all pregnancies reported as unintended. Integrated HIV and reproductive health care programming is required to better support WLWH to optimize pregnancy planning and outcomes and to prevent unintended pregnancy.

Indexed as

IntentionPregnancy, UnplannedSexual BehaviorWomen's HealthAdultAnti-HIV AgentsCanadaFamily Planning ServicesFemaleHIV SeropositivityHumansIncidencePregnancyPregnancy RateYoung AdultAnti-HIV Agents

Identifiers

PMID28727731
PMCPMC5519029
OpenAlexW2737465716

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.