ArticleInternational journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists2017
Granulosa Cell Tumors: Novel Predictors of Recurrence in Early-stage Patients.
Article in International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed.
- Female Aging Affects Coilin Pattern in Mouse Cumulus Cells.Journal of developmental biology · 2026Article
- A molecular and immunohistochemical study of 37 cases of ovarian Sertoli-Leydig cell tumor.Virchows Archiv : an international journal of pathology · 2025Article
- Article
- Complex immunohistochemical and molecular study on 5 cases of ovarian juvenile granulosa cell tumors reveals a consistent alteration in the PI3K/AKT/mTOR signaling pathway.Diagnostic pathology · 2025Article
- Intraoperative Diagnosis: Imprint Cytology and Frozen Section in Ovarian Tumor, Averting Additional Surgery.Journal of pharmacy & bioallied sciences · 2024Article
- Advanced Granulosa Cell Tumors of the Ovary: A Review with a Focus on Current and Novel Therapeutic Approaches.Journal of immunotherapy and precision oncology · 2024Review
- An extensive immunohistochemical analysis of 290 ovarian adult granulosa cell tumors with 29 markers.Virchows Archiv : an international journal of pathology · 2024Article
- A clinicopathological study about the epidemiology of granulosa cell tumors in Lebanon.BMC cancer · 2024Article
- Immunohistochemical markers of prognosis in adult granulosa cell tumors of the ovary - a review.Journal of ovarian research · 2023Review
- Inhibin Alpha Expression in Human Tumors: A Tissue Microarray Study on 12,212 Tumors.Biomedicines · 2022Article
- Can adjuvant chemotherapy improve the prognosis of adult ovarian granulosa cell tumors?: A narrative review.Medicine · 2022Review
- Cytologic features of sex cord-stromal tumors in women.Cancer cytopathology · 2022Article
- Adult Granulosa Cell Tumor in Pregnancy: A New Case and a Review of the Literature.Healthcare (Basel, Switzerland) · 2021Review
- Research Progress in Prognostic Factors and Biomarkers of Ovarian Cancer.Journal of Cancer · 2021Review
- New insights into testicular granulosa cell tumors.Oncology letters · 2020Review
- Centromere protein U facilitates metastasis of ovarian cancer cells by targeting high mobility group box 2 expression.American journal of cancer research · 2018Article
- Late retroperitoneal recurrence of adult-type ovarian granulosa cell tumors: Two case reports and literature review.Science progressReview
- Magnetic Resonance Imaging of Recurrent Adult Granulosa Cell Tumor of the Ovary: A Retrospective Analysis of 11 Cases.Journal of computer assisted tomographyArticle
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8 authors.
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Abstract
Granulosa cell tumors (GCTs) comprise 2% to 5% of ovarian neoplasms, with unpredictable patterns of recurrence. The HER family, GATA4, and SMAD3 genes are reportedly involved in GCT proliferation and apoptosis and may serve as new predictors of recurrence. The aim of the study was to evaluate novel predictors of recurrence in GCT from a large single institution cohort. Patients diagnosed with GCTs (n=125) between 1975 and 2014 were identified. Clinicopathologic parameters were obtained and immunohistochemical evaluation was performed of calretinin, inhibin, HER2, CD56, SMAD3, and GATA4. Statistical analyses were conducted using Fisher exact test and Kaplan-Meier survival curves and Cox regression analysis. The median follow-up period was 120 months (range, 1-465 mo). Recurrence was noted in 12/125 (9.6%) patients. Kaplan-Meier analysis showed a shorter mean disease-free interval in whites versus blacks (P=0.001), stage III-IV versus stage I-II (P=0.0001), patients treated with surgery+chemotherapy versus surgery (P=0.0001), mitotic rate ≥4 (P=0.005), severe nuclear pleomorphism (P=0.013), high HER2 expression (P=0.001), high CD56 expression (P=0.001), and high SMAD3 expression (P=0.001). On Cox regression analysis, SMAD3 and type of treatment received were the only 2 independent prognostic factors for disease-free interval (P=0.03 and P=0.007, respectively). On subanalysis for early-stage (stage I) GCTs, the need for adjuvant chemotherapy and high expression of SMAD3 continued to be independent predictors of recurrence (HR=10.2, P=0.01 and HR=8.9, P=0.001, respectively).
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