Trial reportAnesthesiology2017
Perioperative Gabapentin Does Not Reduce Postoperative Delirium in Older Surgical Patients: A Randomized Clinical Trial.
Trial report in Anesthesiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00221338 (Clinical Trial of Gabapentin to Decrease Postoperative Delirium and Pain in Surgical Patients), which is not on this map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Trial of Gabapentin to Decrease Postoperative Delirium and Pain in Surgical Patients
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Non-pharmacological interventions for managing acute pain and delirium in hospitalized older patients: a systematic review.BMC geriatrics · 2025Pooled it
- Prevention of postoperative delirium in elderly patients planned for elective surgery: systematic review and meta-analysis.Clinical interventions in aging · 2019Pooled it
- Evolving Trends and Collaborative Networks in Postoperative Delirium Research: A Two-Decade Bibliometric Analysis.Brain and behavior · 2026Article
- Diagnosis, Prevention, Management, and Prognostication of Delirium in Acute-Care Neurosurgical Patients: A Systematic Scoping Review.Neurocritical care · 2026Review
- Association of preoperative frailty and delayed neurocognitive recovery in older adults undergoing major elective surgery in Thailand: a single centre prospective study.The Lancet regional health. Southeast Asia · 2026Article
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- Article
- Efficacy of intraoperative ketamine/esketamine in the prevention of postoperative delirium: a systematic review and meta-analysis.Therapeutic advances in psychopharmacology · 2025Article
- Gabapentinoids-Related Delirium Adverse Events: A Real-World Study from 2004 to 2022 Based on FAERS.Journal of pain research · 2024Article
- Ramelteon and suvorexant for postoperative delirium in elderly patients with esophageal cancer.Esophagus : official journal of the Japan Esophageal Society · 2023Article
- The Management of Postoperative Cognitive Dysfunction in Cirrhotic Patients: An Overview of the Literature.Medicina (Kaunas, Lithuania) · 2023Review
- Lidocaine Infusion for the Management of Postoperative Pain and Delirium (LIMPP): protocol for a randomised control trial.BMJ open · 2022Article
- Obesity and perioperative outcomes in older surgical patients undergoing elective spine and major arthroplasty surgery.Journal of clinical anesthesia · 2021Article
- Sleep, Pain, and Cognition: Modifiable Targets for Optimal Perioperative Brain Health.Anesthesiology · 2021Review
- Article
- Comparative effectiveness of pharmacological interventions to prevent postoperative delirium: a network meta-analysis.Scientific reports · 2021Article
- Pharmacological strategies to prevent postoperative delirium: a systematic review and network meta-analysis.Anesthesia and pain medicine · 2021Article
- Disease Mechanisms of Perioperative Organ Injury.Anesthesia and analgesia · 2020Review
- Does postoperative delirium following elective noncardiac surgery predict long-term mortality?Age and ageing · 2020Article
- American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on Postoperative Delirium Prevention.Anesthesia and analgesia · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundPostoperative pain and opioid use are associated with postoperative delirium. We designed a single-center, randomized, placebo-controlled, parallel-arm, double-blinded trial to determine whether perioperative administration of gabapentin reduced postoperative delirium after noncardiac surgery.
methodsPatients were randomly assigned to receive placebo (N = 347) or gabapentin 900 mg (N = 350) administered preoperatively and for the first 3 postoperative days. The primary outcome was postoperative delirium as measured by the Confusion Assessment Method. Secondary outcomes were postoperative pain, opioid use, and length of hospital stay.
resultsData for 697 patients were included, with a mean ± SD age of 72 ± 6 yr. The overall incidence of postoperative delirium in any of the first 3 days was 22.4% (24.0% in the gabapentin and 20.8% in the placebo groups; the difference was 3.20%; 95% CI, 3.22% to 9.72%; P = 0.30). The incidence of delirium did not differ between the two groups when stratified by surgery type, anesthesia type, or preoperative risk status. Gabapentin was shown to be opioid sparing, with lower doses for the intervention group versus the control group. For example, the morphine equivalents for the gabapentin-treated group, median 6.7 mg (25th, 75th quartiles: 1.3, 20.0 mg), versus control group, median 6.7 mg (25th, 75th quartiles: 2.7, 24.8 mg), differed on the first postoperative day (P = 0.04).
conclusionsAlthough postoperative opioid use was reduced, perioperative administration of gabapentin did not result in a reduction of postoperative delirium or hospital length of stay.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.