Evidence map›Paper›PMID 28727501›Full record

ArticleRadiology2017

Validation of the Dominant Sequence Paradigm and Role of Dynamic Contrast-enhanced Imaging in PI-RADS Version 2.

Matthew D Greer, Joanna H Shih, Nathan Lay, Tristan Barrett, Leonardo Kayat Bittencourt, Samuel Borofsky, Ismail M Kabakus, Yan Mee Law, Jamie Marko, Haytham Shebel and 7 more

Open access · greenAbstract readEvaluation StudyValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 3 pooled it
15.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 3 syntheses or guidelines pooled it, 160 citations in OpenAlex.

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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Matthew D GreerFrom the Molecular Imaging (M.D.G., F.V.M., P.L.C., B.T.) and Biometric Research (J.H.S.) Programs, Laboratory of Pathology (M.J.M.), and Urologic Oncology Branch (P.A.P.), National Cancer Institute, National Institutes of Health, 10 Center Dr, Room B3B85, Bethesda, MD 20892; Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (N.L., R.M.S.); Department of Radiology, University of Cambridge School of Medicine, Cambridge, England (T.B.); Department of Radiology, Universidade Federal Fluminense, Rio de Janeiro, Brazil (L.K.B.); Department of Body Imaging, CDPI Clinics/DASA, Rio de Janeiro, Brazil (L.K.B.); Department of Radiology, George Washington University Hospital, Washington, DC (S.B.); Department of Radiology, Hacettepe University, Ankara, Turkey (I.M.K.); Department of Diagnostic Radiology Singapore General Hospital, Singapore (Y.M.L.); Department of Radiology, Walter Reed National Military Medical Center, Bethesda, Md (J.M.); Department of Radiology, Nephrology Center, Mansoura University, Mansoura, Egypt (H.S.); Center for Interventional Oncology, National Cancer Institute and Clinical Center, and Radiology Imaging Sciences, National Institutes of Health, Bethesda, Md (B.J.W.).
Joanna H ShihFrom the Molecular Imaging (M.D.G., F.V.M., P.L.C., B.T.) and Biometric Research (J.H.S.) Programs, Laboratory of Pathology (M.J.M.), and Urologic Oncology Branch (P.A.P.), National Cancer Institute, National Institutes of Health, 10 Center Dr, Room B3B85, Bethesda, MD 20892; Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (N.L., R.M.S.); Department of Radiology, University of Cambridge School of Medicine, Cambridge, England (T.B.); Department of Radiology, Universidade Federal Fluminense, Rio de Janeiro, Brazil (L.K.B.); Department of Body Imaging, CDPI Clinics/DASA, Rio de Janeiro, Brazil (L.K.B.); Department of Radiology, George Washington University Hospital, Washington, DC (S.B.); Department of Radiology, Hacettepe University, Ankara, Turkey (I.M.K.); Department of Diagnostic Radiology Singapore General Hospital, Singapore (Y.M.L.); Department of Radiology, Walter Reed National Military Medical Center, Bethesda, Md (J.M.); Department of Radiology, Nephrology Center, Mansoura University, Mansoura, Egypt (H.S.); Center for Interventional Oncology, National Cancer Institute and Clinical Center, and Radiology Imaging Sciences, National Institutes of Health, Bethesda, Md (B.J.W.).
Nathan LayFrom the Molecular Imaging (M.D.G., F.V.M., P.L.C., B.T.) and Biometric Research (J.H.S.) Programs, Laboratory of Pathology (M.J.M.), and Urologic Oncology Branch (P.A.P.), National Cancer Institute, National Institutes of Health, 10 Center Dr, Room B3B85, Bethesda, MD 20892; Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (N.L., R.M.S.); Department of Radiology, University of Cambridge School of Medicine, Cambridge, England (T.B.); Department of Radiology, Universidade Federal Fluminense, Rio de Janeiro, Brazil (L.K.B.); Department of Body Imaging, CDPI Clinics/DASA, Rio de Janeiro, Brazil (L.K.B.); Department of Radiology, George Washington University Hospital, Washington, DC (S.B.); Department of Radiology, Hacettepe University, Ankara, Turkey (I.M.K.); Department of Diagnostic Radiology Singapore General Hospital, Singapore (Y.M.L.); Department of Radiology, Walter Reed National Military Medical Center, Bethesda, Md (J.M.); Department of Radiology, Nephrology Center, Mansoura University, Mansoura, Egypt (H.S.); Center for Interventional Oncology, National Cancer Institute and Clinical Center, and Radiology Imaging Sciences, National Institutes of Health, Bethesda, Md (B.J.W.).
Tristan BarrettFrom the Molecular Imaging (M.D.G., F.V.M., P.L.C., B.T.) and Biometric Research (J.H.S.) Programs, Laboratory of Pathology (M.J.M.), and Urologic Oncology Branch (P.A.P.), National Cancer Institute, National Institutes of Health, 10 Center Dr, Room B3B85, Bethesda, MD 20892; Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (N.L., R.M.S.); Department of Radiology, University of Cambridge School of Medicine, Cambridge, England (T.B.); Department of Radiology, Universidade Federal Fluminense, Rio de Janeiro, Brazil (L.K.B.); Department of Body Imaging, CDPI Clinics/DASA, Rio de Janeiro, Brazil (L.K.B.); Department of Radiology, George Washington University Hospital, Washington, DC (S.B.); Department of Radiology, Hacettepe University, Ankara, Turkey (I.M.K.); Department of Diagnostic Radiology Singapore General Hospital, Singapore (Y.M.L.); Department of Radiology, Walter Reed National Military Medical Center, Bethesda, Md (J.M.); Department of Radiology, Nephrology Center, Mansoura University, Mansoura, Egypt (H.S.); Center for Interventional Oncology, National Cancer Institute and Clinical Center, and Radiology Imaging Sciences, National Institutes of Health, Bethesda, Md (B.J.W.).
Leonardo Kayat BittencourtFrom the Molecular Imaging (M.D.G., F.V.M., P.L.C., B.T.) and Biometric Research (J.H.S.) Programs, Laboratory of Pathology (M.J.M.), and Urologic Oncology Branch (P.A.P.), National Cancer Institute, National Institutes of Health, 10 Center Dr, Room B3B85, Bethesda, MD 20892; Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (N.L., R.M.S.); Department of Radiology, University of Cambridge School of Medicine, Cambridge, England (T.B.); Department of Radiology, Universidade Federal Fluminense, Rio de Janeiro, Brazil (L.K.B.); Department of Body Imaging, CDPI Clinics/DASA, Rio de Janeiro, Brazil (L.K.B.); Department of Radiology, George Washington University Hospital, Washington, DC (S.B.); Department of Radiology, Hacettepe University, Ankara, Turkey (I.M.K.); Department of Diagnostic Radiology Singapore General Hospital, Singapore (Y.M.L.); Department of Radiology, Walter Reed National Military Medical Center, Bethesda, Md (J.M.); Department of Radiology, Nephrology Center, Mansoura University, Mansoura, Egypt (H.S.); Center for Interventional Oncology, National Cancer Institute and Clinical Center, and Radiology Imaging Sciences, National Institutes of Health, Bethesda, Md (B.J.W.).
Samuel BorofskyFrom the Molecular Imaging (M.D.G., F.V.M., P.L.C., B.T.) and Biometric Research (J.H.S.) Programs, Laboratory of Pathology (M.J.M.), and Urologic Oncology Branch (P.A.P.), National Cancer Institute, National Institutes of Health, 10 Center Dr, Room B3B85, Bethesda, MD 20892; Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (N.L., R.M.S.); Department of Radiology, University of Cambridge School of Medicine, Cambridge, England (T.B.); Department of Radiology, Universidade Federal Fluminense, Rio de Janeiro, Brazil (L.K.B.); Department of Body Imaging, CDPI Clinics/DASA, Rio de Janeiro, Brazil (L.K.B.); Department of Radiology, George Washington University Hospital, Washington, DC (S.B.); Department of Radiology, Hacettepe University, Ankara, Turkey (I.M.K.); Department of Diagnostic Radiology Singapore General Hospital, Singapore (Y.M.L.); Department of Radiology, Walter Reed National Military Medical Center, Bethesda, Md (J.M.); Department of Radiology, Nephrology Center, Mansoura University, Mansoura, Egypt (H.S.); Center for Interventional Oncology, National Cancer Institute and Clinical Center, and Radiology Imaging Sciences, National Institutes of Health, Bethesda, Md (B.J.W.).
Ismail M KabakusFrom the Molecular Imaging (M.D.G., F.V.M., P.L.C., B.T.) and Biometric Research (J.H.S.) Programs, Laboratory of Pathology (M.J.M.), and Urologic Oncology Branch (P.A.P.), National Cancer Institute, National Institutes of Health, 10 Center Dr, Room B3B85, Bethesda, MD 20892; Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (N.L., R.M.S.); Department of Radiology, University of Cambridge School of Medicine, Cambridge, England (T.B.); Department of Radiology, Universidade Federal Fluminense, Rio de Janeiro, Brazil (L.K.B.); Department of Body Imaging, CDPI Clinics/DASA, Rio de Janeiro, Brazil (L.K.B.); Department of Radiology, George Washington University Hospital, Washington, DC (S.B.); Department of Radiology, Hacettepe University, Ankara, Turkey (I.M.K.); Department of Diagnostic Radiology Singapore General Hospital, Singapore (Y.M.L.); Department of Radiology, Walter Reed National Military Medical Center, Bethesda, Md (J.M.); Department of Radiology, Nephrology Center, Mansoura University, Mansoura, Egypt (H.S.); Center for Interventional Oncology, National Cancer Institute and Clinical Center, and Radiology Imaging Sciences, National Institutes of Health, Bethesda, Md (B.J.W.).
Yan Mee LawFrom the Molecular Imaging (M.D.G., F.V.M., P.L.C., B.T.) and Biometric Research (J.H.S.) Programs, Laboratory of Pathology (M.J.M.), and Urologic Oncology Branch (P.A.P.), National Cancer Institute, National Institutes of Health, 10 Center Dr, Room B3B85, Bethesda, MD 20892; Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (N.L., R.M.S.); Department of Radiology, University of Cambridge School of Medicine, Cambridge, England (T.B.); Department of Radiology, Universidade Federal Fluminense, Rio de Janeiro, Brazil (L.K.B.); Department of Body Imaging, CDPI Clinics/DASA, Rio de Janeiro, Brazil (L.K.B.); Department of Radiology, George Washington University Hospital, Washington, DC (S.B.); Department of Radiology, Hacettepe University, Ankara, Turkey (I.M.K.); Department of Diagnostic Radiology Singapore General Hospital, Singapore (Y.M.L.); Department of Radiology, Walter Reed National Military Medical Center, Bethesda, Md (J.M.); Department of Radiology, Nephrology Center, Mansoura University, Mansoura, Egypt (H.S.); Center for Interventional Oncology, National Cancer Institute and Clinical Center, and Radiology Imaging Sciences, National Institutes of Health, Bethesda, Md (B.J.W.).
Jamie MarkoFrom the Molecular Imaging (M.D.G., F.V.M., P.L.C., B.T.) and Biometric Research (J.H.S.) Programs, Laboratory of Pathology (M.J.M.), and Urologic Oncology Branch (P.A.P.), National Cancer Institute, National Institutes of Health, 10 Center Dr, Room B3B85, Bethesda, MD 20892; Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (N.L., R.M.S.); Department of Radiology, University of Cambridge School of Medicine, Cambridge, England (T.B.); Department of Radiology, Universidade Federal Fluminense, Rio de Janeiro, Brazil (L.K.B.); Department of Body Imaging, CDPI Clinics/DASA, Rio de Janeiro, Brazil (L.K.B.); Department of Radiology, George Washington University Hospital, Washington, DC (S.B.); Department of Radiology, Hacettepe University, Ankara, Turkey (I.M.K.); Department of Diagnostic Radiology Singapore General Hospital, Singapore (Y.M.L.); Department of Radiology, Walter Reed National Military Medical Center, Bethesda, Md (J.M.); Department of Radiology, Nephrology Center, Mansoura University, Mansoura, Egypt (H.S.); Center for Interventional Oncology, National Cancer Institute and Clinical Center, and Radiology Imaging Sciences, National Institutes of Health, Bethesda, Md (B.J.W.).
Haytham ShebelFrom the Molecular Imaging (M.D.G., F.V.M., P.L.C., B.T.) and Biometric Research (J.H.S.) Programs, Laboratory of Pathology (M.J.M.), and Urologic Oncology Branch (P.A.P.), National Cancer Institute, National Institutes of Health, 10 Center Dr, Room B3B85, Bethesda, MD 20892; Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (N.L., R.M.S.); Department of Radiology, University of Cambridge School of Medicine, Cambridge, England (T.B.); Department of Radiology, Universidade Federal Fluminense, Rio de Janeiro, Brazil (L.K.B.); Department of Body Imaging, CDPI Clinics/DASA, Rio de Janeiro, Brazil (L.K.B.); Department of Radiology, George Washington University Hospital, Washington, DC (S.B.); Department of Radiology, Hacettepe University, Ankara, Turkey (I.M.K.); Department of Diagnostic Radiology Singapore General Hospital, Singapore (Y.M.L.); Department of Radiology, Walter Reed National Military Medical Center, Bethesda, Md (J.M.); Department of Radiology, Nephrology Center, Mansoura University, Mansoura, Egypt (H.S.); Center for Interventional Oncology, National Cancer Institute and Clinical Center, and Radiology Imaging Sciences, National Institutes of Health, Bethesda, Md (B.J.W.).
Francesca V MertanFrom the Molecular Imaging (M.D.G., F.V.M., P.L.C., B.T.) and Biometric Research (J.H.S.) Programs, Laboratory of Pathology (M.J.M.), and Urologic Oncology Branch (P.A.P.), National Cancer Institute, National Institutes of Health, 10 Center Dr, Room B3B85, Bethesda, MD 20892; Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (N.L., R.M.S.); Department of Radiology, University of Cambridge School of Medicine, Cambridge, England (T.B.); Department of Radiology, Universidade Federal Fluminense, Rio de Janeiro, Brazil (L.K.B.); Department of Body Imaging, CDPI Clinics/DASA, Rio de Janeiro, Brazil (L.K.B.); Department of Radiology, George Washington University Hospital, Washington, DC (S.B.); Department of Radiology, Hacettepe University, Ankara, Turkey (I.M.K.); Department of Diagnostic Radiology Singapore General Hospital, Singapore (Y.M.L.); Department of Radiology, Walter Reed National Military Medical Center, Bethesda, Md (J.M.); Department of Radiology, Nephrology Center, Mansoura University, Mansoura, Egypt (H.S.); Center for Interventional Oncology, National Cancer Institute and Clinical Center, and Radiology Imaging Sciences, National Institutes of Health, Bethesda, Md (B.J.W.).
Maria J MerinoFrom the Molecular Imaging (M.D.G., F.V.M., P.L.C., B.T.) and Biometric Research (J.H.S.) Programs, Laboratory of Pathology (M.J.M.), and Urologic Oncology Branch (P.A.P.), National Cancer Institute, National Institutes of Health, 10 Center Dr, Room B3B85, Bethesda, MD 20892; Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (N.L., R.M.S.); Department of Radiology, University of Cambridge School of Medicine, Cambridge, England (T.B.); Department of Radiology, Universidade Federal Fluminense, Rio de Janeiro, Brazil (L.K.B.); Department of Body Imaging, CDPI Clinics/DASA, Rio de Janeiro, Brazil (L.K.B.); Department of Radiology, George Washington University Hospital, Washington, DC (S.B.); Department of Radiology, Hacettepe University, Ankara, Turkey (I.M.K.); Department of Diagnostic Radiology Singapore General Hospital, Singapore (Y.M.L.); Department of Radiology, Walter Reed National Military Medical Center, Bethesda, Md (J.M.); Department of Radiology, Nephrology Center, Mansoura University, Mansoura, Egypt (H.S.); Center for Interventional Oncology, National Cancer Institute and Clinical Center, and Radiology Imaging Sciences, National Institutes of Health, Bethesda, Md (B.J.W.).
Bradford J WoodFrom the Molecular Imaging (M.D.G., F.V.M., P.L.C., B.T.) and Biometric Research (J.H.S.) Programs, Laboratory of Pathology (M.J.M.), and Urologic Oncology Branch (P.A.P.), National Cancer Institute, National Institutes of Health, 10 Center Dr, Room B3B85, Bethesda, MD 20892; Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (N.L., R.M.S.); Department of Radiology, University of Cambridge School of Medicine, Cambridge, England (T.B.); Department of Radiology, Universidade Federal Fluminense, Rio de Janeiro, Brazil (L.K.B.); Department of Body Imaging, CDPI Clinics/DASA, Rio de Janeiro, Brazil (L.K.B.); Department of Radiology, George Washington University Hospital, Washington, DC (S.B.); Department of Radiology, Hacettepe University, Ankara, Turkey (I.M.K.); Department of Diagnostic Radiology Singapore General Hospital, Singapore (Y.M.L.); Department of Radiology, Walter Reed National Military Medical Center, Bethesda, Md (J.M.); Department of Radiology, Nephrology Center, Mansoura University, Mansoura, Egypt (H.S.); Center for Interventional Oncology, National Cancer Institute and Clinical Center, and Radiology Imaging Sciences, National Institutes of Health, Bethesda, Md (B.J.W.).
Peter A PintoFrom the Molecular Imaging (M.D.G., F.V.M., P.L.C., B.T.) and Biometric Research (J.H.S.) Programs, Laboratory of Pathology (M.J.M.), and Urologic Oncology Branch (P.A.P.), National Cancer Institute, National Institutes of Health, 10 Center Dr, Room B3B85, Bethesda, MD 20892; Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (N.L., R.M.S.); Department of Radiology, University of Cambridge School of Medicine, Cambridge, England (T.B.); Department of Radiology, Universidade Federal Fluminense, Rio de Janeiro, Brazil (L.K.B.); Department of Body Imaging, CDPI Clinics/DASA, Rio de Janeiro, Brazil (L.K.B.); Department of Radiology, George Washington University Hospital, Washington, DC (S.B.); Department of Radiology, Hacettepe University, Ankara, Turkey (I.M.K.); Department of Diagnostic Radiology Singapore General Hospital, Singapore (Y.M.L.); Department of Radiology, Walter Reed National Military Medical Center, Bethesda, Md (J.M.); Department of Radiology, Nephrology Center, Mansoura University, Mansoura, Egypt (H.S.); Center for Interventional Oncology, National Cancer Institute and Clinical Center, and Radiology Imaging Sciences, National Institutes of Health, Bethesda, Md (B.J.W.).
Ronald M SummersFrom the Molecular Imaging (M.D.G., F.V.M., P.L.C., B.T.) and Biometric Research (J.H.S.) Programs, Laboratory of Pathology (M.J.M.), and Urologic Oncology Branch (P.A.P.), National Cancer Institute, National Institutes of Health, 10 Center Dr, Room B3B85, Bethesda, MD 20892; Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (N.L., R.M.S.); Department of Radiology, University of Cambridge School of Medicine, Cambridge, England (T.B.); Department of Radiology, Universidade Federal Fluminense, Rio de Janeiro, Brazil (L.K.B.); Department of Body Imaging, CDPI Clinics/DASA, Rio de Janeiro, Brazil (L.K.B.); Department of Radiology, George Washington University Hospital, Washington, DC (S.B.); Department of Radiology, Hacettepe University, Ankara, Turkey (I.M.K.); Department of Diagnostic Radiology Singapore General Hospital, Singapore (Y.M.L.); Department of Radiology, Walter Reed National Military Medical Center, Bethesda, Md (J.M.); Department of Radiology, Nephrology Center, Mansoura University, Mansoura, Egypt (H.S.); Center for Interventional Oncology, National Cancer Institute and Clinical Center, and Radiology Imaging Sciences, National Institutes of Health, Bethesda, Md (B.J.W.).
Peter L ChoykeFrom the Molecular Imaging (M.D.G., F.V.M., P.L.C., B.T.) and Biometric Research (J.H.S.) Programs, Laboratory of Pathology (M.J.M.), and Urologic Oncology Branch (P.A.P.), National Cancer Institute, National Institutes of Health, 10 Center Dr, Room B3B85, Bethesda, MD 20892; Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (N.L., R.M.S.); Department of Radiology, University of Cambridge School of Medicine, Cambridge, England (T.B.); Department of Radiology, Universidade Federal Fluminense, Rio de Janeiro, Brazil (L.K.B.); Department of Body Imaging, CDPI Clinics/DASA, Rio de Janeiro, Brazil (L.K.B.); Department of Radiology, George Washington University Hospital, Washington, DC (S.B.); Department of Radiology, Hacettepe University, Ankara, Turkey (I.M.K.); Department of Diagnostic Radiology Singapore General Hospital, Singapore (Y.M.L.); Department of Radiology, Walter Reed National Military Medical Center, Bethesda, Md (J.M.); Department of Radiology, Nephrology Center, Mansoura University, Mansoura, Egypt (H.S.); Center for Interventional Oncology, National Cancer Institute and Clinical Center, and Radiology Imaging Sciences, National Institutes of Health, Bethesda, Md (B.J.W.).
Baris TurkbeyFrom the Molecular Imaging (M.D.G., F.V.M., P.L.C., B.T.) and Biometric Research (J.H.S.) Programs, Laboratory of Pathology (M.J.M.), and Urologic Oncology Branch (P.A.P.), National Cancer Institute, National Institutes of Health, 10 Center Dr, Room B3B85, Bethesda, MD 20892; Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (N.L., R.M.S.); Department of Radiology, University of Cambridge School of Medicine, Cambridge, England (T.B.); Department of Radiology, Universidade Federal Fluminense, Rio de Janeiro, Brazil (L.K.B.); Department of Body Imaging, CDPI Clinics/DASA, Rio de Janeiro, Brazil (L.K.B.); Department of Radiology, George Washington University Hospital, Washington, DC (S.B.); Department of Radiology, Hacettepe University, Ankara, Turkey (I.M.K.); Department of Diagnostic Radiology Singapore General Hospital, Singapore (Y.M.L.); Department of Radiology, Walter Reed National Military Medical Center, Bethesda, Md (J.M.); Department of Radiology, Nephrology Center, Mansoura University, Mansoura, Egypt (H.S.); Center for Interventional Oncology, National Cancer Institute and Clinical Center, and Radiology Imaging Sciences, National Institutes of Health, Bethesda, Md (B.J.W.).
National Institutes of Health · US

Funding

Prostate Cancer ImagingZIABC010655 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CHOYKE, PETER L · 2009 to 2025
$49.2M
Center for Interventional OncologyZIDBC011242 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WOOD, BRADFORD J · 2009 to 2025
$18.7M
Prostate SectionZIABC011081 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI PINTO, PETER · 2009 to 2025
$15.2M
Computer Aided Detection for Radiologic ImagesZIACL040004 · CLC · CLINICAL CENTER · PI SUMMERS, RONALD M. · 2009 to 2025
$0k
Interventional OncologyZIACL040015 · CLC · CLINICAL CENTER · PI WOOD, BRADFORD · 2009 to 2025
$0k
Intramural NIH HHS ZIA BC010655
6 · The paper itself

Abstract

Purpose To validate the dominant pulse sequence paradigm and limited role of dynamic contrast material-enhanced magnetic resonance (MR) imaging in the Prostate Imaging Reporting and Data System (PI-RADS) version 2 for prostate multiparametric MR imaging by using data from a multireader study. Materials and Methods This HIPAA-compliant retrospective interpretation of prospectively acquired data was approved by the local ethics committee. Patients were treatment-naïve with endorectal coil 3-T multiparametric MR imaging. A total of 163 patients were evaluated, 110 with prostatectomy after multiparametric MR imaging and 53 with negative multiparametric MR imaging and systematic biopsy findings. Nine radiologists participated in this study and interpreted images in 58 patients, on average (range, 56-60 patients). Lesions were detected with PI-RADS version 2 and were compared with whole-mount prostatectomy findings. Probability of cancer detection for overall, T2-weighted, and diffusion-weighted (DW) imaging PI-RADS scores was calculated in the peripheral zone (PZ) and transition zone (TZ) by using generalized estimating equations. To determine dominant pulse sequence and benefit of dynamic contrast-enhanced (DCE) imaging, odds ratios (ORs) were calculated as the ratio of odds of cancer of two consecutive scores by logistic regression. Results A total of 654 lesions (420 in the PZ) were detected. The probability of cancer detection for PI-RADS category 2, 3, 4, and 5 lesions was 15.7%, 33.1%, 70.5%, and 90.7%, respectively. DW imaging outperformed T2-weighted imaging in the PZ (OR, 3.49 vs 2.45; P = .008). T2-weighted imaging performed better but did not clearly outperform DW imaging in the TZ (OR, 4.79 vs 3.77; P = .494). Lesions classified as PI-RADS category 3 at DW MR imaging and as positive at DCE imaging in the PZ showed a higher probability of cancer detection than did DCE-negative PI-RADS category 3 lesions (67.8% vs 40.0%, P = .02). The addition of DCE imaging to DW imaging in the PZ was beneficial (OR, 2.0; P = .027), with an increase in the probability of cancer detection of 15.7%, 16.0%, and 9.2% for PI-RADS category 2, 3, and 4 lesions, respectively. Conclusion DW imaging outperforms T2-weighted imaging in the PZ; T2-weighted imaging did not show a significant difference when compared with DW imaging in the TZ by PI-RADS version 2 criteria. The addition of DCE imaging to DW imaging scores in the PZ yields meaningful improvements in probability of cancer detection.

Indexed as

AlgorithmsContrast MediaGuidelines as TopicSignal Processing, Computer-AssistedAdultAgedAged, 80 and overHumansImage Interpretation, Computer-AssistedInternationalityMaleMiddle AgedProstatic NeoplasmsReproducibility of ResultsSensitivity and SpecificityContrast Media

Identifiers

PMID28727501
PMCPMC5708285
OpenAlexW2739119600

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