Evidence map›Paper›PMID 28727288›Full record

ArticlePediatric blood & cancer2017

Complications preceding early deaths in Black and White children with acute myeloid leukemia.

Lena E Winestone, Kelly D Getz, Tamara P Miller, Yimei Li, Yuan-Shung Huang, Alix E Seif, Brian T Fisher, Richard Aplenc

Abstract read
In one paragraph

Article in Pediatric blood & cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lena E WinestoneDivision of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.ORCID http://orcid.org/0000-0001-9982-1594
Kelly D GetzDivision of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Tamara P MillerDivision of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.ORCID http://orcid.org/0000-0003-4250-5376
Yimei LiDepartment of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Yuan-Shung HuangHealthcare Analytics Unit, Department of General Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Alix E SeifDivision of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.ORCID http://orcid.org/0000-0002-1799-2582
Brian T FisherCenter for Pediatric Clinical Effectiveness, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Richard AplencDivision of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Funding

UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI SHELLEY L BERGER · 1985 to 2026
$222.3M
Physician Scientist Training in Clinical OncologyK12CA076931 · NCI · UNIVERSITY OF PENNSYLVANIA · PI STEPHEN Patrick HUNGER, LYNN M. SCHUCHTER · 1997 to 2026
$16.5M
Pediatric Hospital Epidemiology and Outcomes Research Training ProgramT32HD060550 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI Christopher Peter Bonafide, John Chris Feudtner · 2010 to 2026
$6.8M
NCI NIH HHS K12 CA076931NCI NIH HHS P30 CA016520NICHD NIH HHS T32 HD060550
6 · The paper itself

Abstract

Black patients have a twofold increased risk of induction mortality compared to White patients with acute myeloid leukemia (AML). We reviewed diagnosis and billing data from Pediatric Health Information System for 28 AML Induction I deaths to investigate conditions preceding death in White and Black patients. Half of deaths occurred within 10 days of initial diagnostic admission. Respiratory, cardiac, renal, and infectious complications were common prior to both White and Black deaths. Deaths in White patients were more commonly preceded by intracranial hemorrhage compared to deaths in Black patients. Future studies should assess management approaches of complications by race to identify modifiable processes that reduce mortality.

Indexed as

ChildHumansLeukemia, Myeloid, AcuteAMLdisparitiesintensive caremortalityoutcomes researchrace

Identifiers

PMID28727288
PMCPMC5733774

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.