ArticleWound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society2017
Scar formation following excisional and burn injuries in a red Duroc pig model.
Article in Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- In Vivo Models for Hypertrophic Scars-A Systematic Review.Medicina (Kaunas, Lithuania) · 2022Pooled it
- Smart Microneedles Regulate Reactive Oxygen Species and Deliver Matrix Metalloproteinases for Pathological Scar Treatment.ACS nano · 2026Article
- Recent advances in animal models for pathological scar research: A comprehensive review of experimental approaches and translational relevance.Animal models and experimental medicine · 2026Review
- Definition of critical skin defect and concepts of structural and functional repairs: Proposal and verification in a rat model.Animal models and experimental medicine · 2026Article
- Therapeutic Effect of Topical Triamcinolone Acetonide Combined With 10600-nm Ablative Fractional Carbon Dioxide Laser or 1565-nm Non-Ablative Fractional Laser on Hypertrophic Scars in the Rabbit Ear Model.Aesthetic plastic surgery · 2026Article
- Laser micropatterned dermal templates support early rete ridge formation and basement membrane deposition when used with cultured epithelial autografts.Burns : journal of the International Society for Burn Injuries · 2025Article
- Comparison of Intact Fish Skin Graft and Allograft as Temporary Coverage for Full-Thickness Burns: A Non-Inferiority Study.Biomedicines · 2024Article
- A tension offloading patch mitigates dermal fibrosis induced by pro-fibrotic skin injections.Research square · 2024Article
- Human In Vitro Skin Models for Wound Healing and Wound Healing Disorders.Biomedicines · 2023Review
- Comparison of biopolymer scaffolds for the fabrication of skin substitutes in a porcine wound model.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2023Article
- Skin 11β-hydroxysteroid dehydrogenase type 1 enzyme expression regulates burn wound healing and can be targeted to modify scar characteristics.Burns & trauma · 2023Article
- The Role of Local Inflammation and Hypoxia in the Formation of Hypertrophic Scars-A New Model in the Duroc Pig.International journal of molecular sciences · 2022Article
- Comparative Transcriptome Analysis of Superficial and Deep Partial-Thickness Burn Wounds in Yorkshire vs Red Duroc Pigs.Journal of burn care & research : official publication of the American Burn Association · 2022Article
- A Systematic Review Comparing Animal and Human Scarring Models.Frontiers in surgery · 2022Review
- A novel mouse wound model for scar tissue formation in abdominal muscle wall.The Journal of veterinary medical science · 2021Article
- [Roles of interleukin-6/signal transduction and activator of transcription 3 pathway andZhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns · 2021Article
- Pre-Clinical Assessment of Single-Use Negative Pressure Wound Therapy DuringAdvances in wound care · 2021Article
- Recent Advances in Experimental Burn Models.Biology · 2021Review
- Accelerated Wound Closure of Deep Partial Thickness Burns with Acellular Fish Skin Graft.International journal of molecular sciences · 2021Article
- Efficacy and safety of a dual-scan protocol for carbon dioxide laser in the treatment of split-thickness skin graft contraction in a red Duroc pig model.Burns & trauma · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Scar research is challenging because rodents do not naturally form excessive scars, and burn depth, size, and location cannot be controlled in human longitudinal studies. The female, red Duroc pig model has been shown to form robust scars with biological and anatomical similarities to human hypertrophic scars. To more closely mimic the mode of injury, recreate the complex chemical milieu of the burn wound environment and enhance scar development, an animal model of excessive burn-induced scarring was developed and compared with the more commonly used model, which involves excisional wounds created via dermatome. Standardized, full-thickness thermal wounds were created on the dorsum of female, red Duroc pigs. Wounds for the dermatome model were created using two different total dermatome settings: ∼1.5 mm and ≥ 1.9 mm. Results from analysis over 150 days showed that burn wounds healed at much slower rate and contracted more significantly than dermatome wounds of both settings. The burn scars were hairless, had mixed pigmentation, and displayed fourfold and twofold greater excess erythema values, respectively, compared with ∼1.5 mm and ≥ 1.9 mm deep dermatome injuries. Burn scars were less elastic, less pliable, and weaker than scars resulting from excisional injuries. Decorin and versican gene expression levels were elevated in the burn group at day 150 compared with both dermatome groups. In addition, transforming growth factor-beta 1 was significantly up-regulated in the burn group vs. the ∼1.5 mm deep dermatome group at all time points, and expression remained significantly elevated vs. both dermatome groups at day 150. Compared with scars from dermatome wounds, the burn scar model described here demonstrates greater similarity to human hypertrophic scar. Thus, this burn scar model may provide an improved platform for studying the pathophysiology of burn-related hypertrophic scarring, investigating current anti-scar therapies, and development of new strategies with greater clinical benefit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.